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Literature summary extracted from
- Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione (2003), Biochemistry, 42, 10238-10245.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.13.11.27 | medicine | mechanism of binding of the inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione used to treat type I tyrosinemia. Enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero | Streptomyces avermitilis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.27 | 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione | mechanism of binding, enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero | Streptomyces avermitilis |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.27 | Iron | - |
Streptomyces avermitilis | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.27 | Streptomyces avermitilis | - |
- |
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