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Literature summary extracted from

  • Suckling, R.J.; Murphy, G.M.; Higgins, M.J.P.
    Human liver bile acid sulfotransferase: characterization of the partially purified enzyme (1993), Biochem. Soc. Trans., 21, 447S.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.34 lithocholate substrate inhibition Homo sapiens
2.8.2.34 ursodeoxycholate mixed inhibition type Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.34 0.0016
-
lithocholate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.34 additional information Homo sapiens the sulfation reaction may be a protective mechanism against the hepatotoxic effects of some bile acids in facilitating the excretion ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.34 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.34 partially from liver by ion exchange chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.34 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.34 3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone i.e. androst-5-ene-3beta-ol-17-one Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
?
2.8.2.34 3'-phosphoadenylyl 5'-phosphosulfate + estrone
-
Homo sapiens adenosine 3',5'-bisphosphate + estrone 7-sulfate
-
?
2.8.2.34 3'-phosphoadenylyl 5'-phosphosulfate + lithocholate
-
Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
?
2.8.2.34 3'-phosphoadenylyl 5'-phosphosulfate + phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + phenyl sulfate
-
?
2.8.2.34 additional information the sulfation reaction may be a protective mechanism against the hepatotoxic effects of some bile acids in facilitating the excretion Homo sapiens ?
-
?
2.8.2.34 additional information poor activity with ursodeoxycholate and chenodeoxycholate, enzyme shows quite strict substrate specificity Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.34 BAST
-
Homo sapiens
2.8.2.34 bile acid sulfotransferase
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.34 0.1
-
ursodeoxycholate
-
Homo sapiens