EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.10.5.1 | 2.1 A resolution | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | NAD(P)H + H+ + a quinone | Homo sapiens | the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes | NAD(P)+ + a hydroquinone | - |
? | |
1.10.5.1 | additional information | Mus musculus | by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis | ? | - |
? | |
1.10.5.1 | additional information | Homo sapiens | high QR2 activity might make individuals more susceptible to Parkinsons disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.2 | Homo sapiens | P15559 | comparison with quinone reductase 2 | - |
1.10.5.1 | Homo sapiens | P16083 | comparison with quinone reductase 1 | - |
1.10.5.1 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.5.2 | liver | traces | Homo sapiens | - |
1.6.5.2 | additional information | no expression in erythrocytes | Homo sapiens | - |
1.10.5.1 | brain | minimal expression | Homo sapiens | - |
1.10.5.1 | erythrocyte | modest level | Homo sapiens | - |
1.10.5.1 | heart | - |
Homo sapiens | - |
1.10.5.1 | kidney | - |
Homo sapiens | - |
1.10.5.1 | liver | - |
Homo sapiens | - |
1.10.5.1 | liver | high expression level | Homo sapiens | - |
1.10.5.1 | additional information | no expression in placenta | Homo sapiens | - |
1.10.5.1 | additional information | no expression in skeletal muscle | Mus musculus | - |
1.10.5.1 | pancreas | minimal expression | Homo sapiens | - |
1.10.5.1 | skeletal muscle | high expression level | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | NAD(P)H + H+ + a quinone | the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes | Homo sapiens | NAD(P)+ + a hydroquinone | - |
? | |
1.10.5.1 | additional information | by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis | Mus musculus | ? | - |
? | |
1.10.5.1 | additional information | high QR2 activity might make individuals more susceptible to Parkinsons disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite | Homo sapiens | ? | - |
? | |
1.10.5.1 | additional information | enzyme cannot use NADH or NADPH as reducing agent | Homo sapiens | ? | - |
? | |
1.10.5.1 | N-benzyldihydronicotinamide + menadione | - |
Mus musculus | ? | - |
? | |
1.10.5.1 | N-methyldihydronicotinamide + menadione | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.5.2 | NRH:quinone reductase 1 | - |
Homo sapiens |
1.6.5.2 | QR1 | - |
Homo sapiens |
1.6.5.2 | quinone reductase 1 | - |
Homo sapiens |
1.10.5.1 | NRH:quinone reductase 2 | - |
Mus musculus |
1.10.5.1 | NRH:quinone reductase 2 | - |
Homo sapiens |
1.10.5.1 | QR2 | - |
Mus musculus |
1.10.5.1 | QR2 | - |
Homo sapiens |
1.10.5.1 | quinone reductase 2 | - |
Mus musculus |
1.10.5.1 | quinone reductase 2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.6.5.2 | NAD(P)H | Gly149, Tyr155 and His161 are directly involved in the electron transfer from NAD(P)H to FAD and from FADH2 to the quinone | Homo sapiens | |
1.10.5.1 | FAD | contains 1 FAD per monomer firmly bound to the enzyme through multiple interactions | Homo sapiens | |
1.10.5.1 | additional information | enzyme cannot use NADH or NADPH as reducing agent | Homo sapiens |