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Literature summary extracted from

  • Jeitner, T.M.; Delikatny, E.J.; Ahlqvist, J.; Capper, H.; Cooper, A.J.
    Mechanism for the inhibition of transglutaminase 2 by cystamine (2005), Biochem. Pharmacol., 69, 961-970.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 2-Aminophenol
-
Cavia porcellus
2.3.2.13 2-Aminothiophenol
-
Cavia porcellus
2.3.2.13 3-Aminophenol
-
Cavia porcellus
2.3.2.13 3-aminothiophenol
-
Cavia porcellus
2.3.2.13 4-Aminophenol
-
Cavia porcellus
2.3.2.13 4-aminothiophenol
-
Cavia porcellus
2.3.2.13 beta-mercaptoethanolamine mechanism of inhibition, mercapto group significantly influences substrate behaviour Cavia porcellus
2.3.2.13 beta-selenoethanolamine
-
Cavia porcellus
2.3.2.13 butanolamine
-
Cavia porcellus
2.3.2.13 ethanolamine
-
Cavia porcellus
2.3.2.13 additional information not inhibitory: beta-mercaptoethanol Cavia porcellus
2.3.2.13 propanolamine
-
Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
commercial preparation
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 liver
-
Cavia porcellus
-

Storage Stability

EC Number Storage Stability Organism
2.3.2.13 commercial preparation of enzyme loses activity within hours of dissolution in various buffers at 0°C. Stabilization of enzyme by dissolving extract at 70 mU/min in 10 mM DTT and 1 mM diethylenetriaminepentaacetic acid, pH 7.0. Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 dansylcadaverine + N,N-dimethylcasein
-
Cavia porcellus ?
-
?
2.3.2.13 putrescine + N,N-dimethylcasein
-
Cavia porcellus ?
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.13 0.147
-
beta-mercaptoethanolamine pH 8.0, 37°C Cavia porcellus
2.3.2.13 0.16
-
2-Aminothiophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 0.16
-
3-aminothiophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 0.28
-
butanolamine pH 8.0, 37°C Cavia porcellus
2.3.2.13 0.63
-
4-aminothiophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 1.04
-
2-Aminophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 1.09
-
4-Aminophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 1.91
-
3-Aminophenol pH 8.0, 37°C Cavia porcellus
2.3.2.13 2.05
-
propanolamine pH 8.0, 37°C Cavia porcellus
2.3.2.13 2.2 9 ethanolamine pH 8.0, 37°C Cavia porcellus
2.3.2.13 5.14
-
beta-selenoethanolamine pH 8.0, 37°C Cavia porcellus