EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.67 | medicine | identification of a novel non-functional allele of the thiopurine S-methyltransferase gene enhances the efficiency of genotyping methods to predict patients at risk of an inadequate response to thiopurine therapy | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.67 | 0.0152 | - |
6-thioguanine | - |
Homo sapiens | |
2.1.1.67 | 0.0188 | - |
6-thioguanine | 1.2fold increase in KM-value compared to wild-type variant | Homo sapiens | |
2.1.1.67 | 0.0448 | - |
6-thioguanine | 2.9fold increase in KM-value compared to wild-type variant | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.67 | Homo sapiens | P51580 | variant Arg163His, i.e. variant TPMT*16, loss-of function allele of TPMT, patients heterozygous for the Arg163His mutation are intermediate methylators | - |
2.1.1.67 | Homo sapiens | P51580 | variant Lys122Thr, i.e. variant TPMT*19, missense mutation in patients with Crohn's disease, patients heterozygous for the Lys122Thr mutation have normal TPMT activity | - |
2.1.1.67 | Homo sapiens | P51580 | wild-type variant TPMT*1 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.67 | S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.67 | thiopurine S-methyltransferase | - |
Homo sapiens |
2.1.1.67 | TPMT | - |
Homo sapiens |