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Literature summary extracted from

  • Sadik, C.D.; Sies, H.; Schewe, T.
    Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action (2003), Biochem. Pharmacol., 65, 773-781.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one IC50: 0.05 mM Glycine max
1.13.11.33 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one IC50: 0.015 mM Oryctolagus cuniculus
1.13.11.33 apigenin IC50: 0.5 mM Glycine max
1.13.11.33 apigenin IC50: 0.18 mM Oryctolagus cuniculus
1.13.11.33 baicalein IC50: 0.035 mM Glycine max
1.13.11.33 baicalein IC50: 0.001 mM Oryctolagus cuniculus
1.13.11.33 chrysin IC50: 1 mM Oryctolagus cuniculus
1.13.11.33 daidzein IC50: 0.25 mM Glycine max
1.13.11.33 daidzein IC50: 0.43 mM Oryctolagus cuniculus
1.13.11.33 epicatechin IC50: 0.06 mM Oryctolagus cuniculus
1.13.11.33 fisetin IC50: 0.0035 mM Glycine max
1.13.11.33 fisetin IC50: 0.0018 mM Oryctolagus cuniculus
1.13.11.33 flavone IC50: 0.7 mM Glycine max
1.13.11.33 flavone IC50: 0.32 mM Oryctolagus cuniculus
1.13.11.33 galangin IC50: 0.2 mM Glycine max
1.13.11.33 galangin IC50: 0.045 mM Oryctolagus cuniculus
1.13.11.33 genistein IC50: 1 mM Glycine max
1.13.11.33 genistein IC50: 0.018 mM Oryctolagus cuniculus
1.13.11.33 hesperetin IC50: 0.09 mM Oryctolagus cuniculus
1.13.11.33 luteolin IC50: 0.003 mM Glycine max
1.13.11.33 luteolin IC50: 0.0006 mM Oryctolagus cuniculus
1.13.11.33 morin IC50: 0.018 mM Glycine max
1.13.11.33 morin IC50: 0.006 mM Oryctolagus cuniculus
1.13.11.33 myricetin IC50: 0.006 mM Glycine max
1.13.11.33 myricetin IC50: 0.018 mM Oryctolagus cuniculus
1.13.11.33 naringenin IC50: 0.25 mM Oryctolagus cuniculus
1.13.11.33 quercetin IC50: 0.0045 mM Glycine max
1.13.11.33 quercetin IC50: 0.004 mM Oryctolagus cuniculus
1.13.11.33 rutin IC50: 1 mM Oryctolagus cuniculus
1.13.11.33 taxifolin IC50: 1 mM Glycine max
1.13.11.33 taxifolin IC50: 0.025 mM Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Glycine max
-
-
-
1.13.11.33 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 reticulocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 linoleic acid + O2
-
Oryctolagus cuniculus ?
-
?
1.13.11.33 linoleic acid + O2
-
Glycine max ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase-1
-
Glycine max
1.13.11.33 lipoxygenase L-1
-
Glycine max
1.13.11.33 reticulocyte 15-lipoxygenase-1
-
Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.0006
-
IC50: 0.0006 mM Oryctolagus cuniculus ABT-384
1.13.11.33 0.001
-
IC50: 0.001 mM Oryctolagus cuniculus baicalein
1.13.11.33 0.0018
-
IC50: 0.0018 mM Oryctolagus cuniculus fisetin
1.13.11.33 0.003
-
IC50: 0.003 mM Glycine max ABT-384
1.13.11.33 0.0035
-
IC50: 0.0035 mM Glycine max fisetin
1.13.11.33 0.004
-
IC50: 0.004 mM Oryctolagus cuniculus quercetin
1.13.11.33 0.0045
-
IC50: 0.0045 mM Glycine max quercetin
1.13.11.33 0.006
-
IC50: 0.006 mM Glycine max myricetin
1.13.11.33 0.006
-
IC50: 0.006 mM Oryctolagus cuniculus morin
1.13.11.33 0.015
-
IC50: 0.015 mM Oryctolagus cuniculus 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
1.13.11.33 0.018
-
IC50: 0.018 mM Oryctolagus cuniculus genistein
1.13.11.33 0.018
-
IC50: 0.018 mM Oryctolagus cuniculus myricetin
1.13.11.33 0.018
-
IC50: 0.018 mM Glycine max morin
1.13.11.33 0.025
-
IC50: 0.025 mM Oryctolagus cuniculus taxifolin
1.13.11.33 0.035
-
IC50: 0.035 mM Glycine max baicalein
1.13.11.33 0.045
-
IC50: 0.045 mM Oryctolagus cuniculus galangin
1.13.11.33 0.05
-
IC50: 0.05 mM Glycine max 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
1.13.11.33 0.06
-
IC50: 0.06 mM Oryctolagus cuniculus epicatechin
1.13.11.33 0.09
-
IC50: 0.09 mM Oryctolagus cuniculus hesperetin
1.13.11.33 0.18
-
IC50: 0.18 mM Oryctolagus cuniculus apigenin
1.13.11.33 0.2
-
IC50: 0.2 mM Glycine max galangin
1.13.11.33 0.25
-
IC50: 0.25 mM Oryctolagus cuniculus naringenin
1.13.11.33 0.25
-
IC50: 0.25 mM Glycine max daidzein
1.13.11.33 0.32
-
IC50: 0.32 mM Oryctolagus cuniculus flavone
1.13.11.33 0.43
-
IC50: 0.43 mM Oryctolagus cuniculus daidzein
1.13.11.33 0.5
-
IC50: 0.5 mM Glycine max apigenin
1.13.11.33 0.7
-
IC50: 0.7 mM Glycine max flavone
1.13.11.33 1
-
IC50: 1 mM Glycine max genistein
1.13.11.33 1
-
IC50: 1 mM Oryctolagus cuniculus rutin
1.13.11.33 1
-
IC50: 1 mM Oryctolagus cuniculus chrysin
1.13.11.33 1
-
IC50: 1 mM Glycine max taxifolin