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Literature summary extracted from

  • McKinney, S.C.; Collins, R.H.; Killenberg, P.G.; Lack, L.
    Effect of 6-methylene-4-pregnene-3,20-dione treatment on hepatic bile acid sulfotransferase activity in male rats (1986), Biochem. Pharmacol., 35, 1050-1052.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.34 6-methylene-4-pregnene-3,20-dione activates the hepatic enzyme in sham-operated and castrated male rats, effect is counteracted by 5alpha-dihydrotestosterone Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.34 5alpha-dihydrotestosterone inhibits the hepatic enzyme in sham-operated and castrated male rats, prevents activation by 6-methylene-4-pregnene-3,20-dione Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.34 Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.34 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.34 0.000012
-
castrated male rats with 5alpha-dihydrotestosterone, hepatic enzyme Rattus norvegicus
2.8.2.34 0.000017
-
sham-operated male rats with 5alpha-dihydrotestosterone, hepatic enzyme Rattus norvegicus
2.8.2.34 0.000019
-
sham-operated male rats with 5alpha-dihydrotestosterone and 6-methylene-4-pregnene-3,20-dione, hepatic enzyme Rattus norvegicus
2.8.2.34 0.000023
-
sham-operated male rats, hepatic enzyme Rattus norvegicus
2.8.2.34 0.000056
-
sham-operated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme Rattus norvegicus
2.8.2.34 0.00006
-
castrated male rats, hepatic enzyme Rattus norvegicus
2.8.2.34 0.000083
-
castrated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme Rattus norvegicus