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Literature summary extracted from

  • Ferry, G.; Ubeaud, C.; Lambert, P.H.; Bertin, S.; Coge, F.; Chomarat, P.; Delagrange, P.; Serkiz, B.; Bouchet, J.P.; Truscott, R.J.W.; Boutin, J.A.
    Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase (2005), Biochem. J., 388, 205-215.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.52 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-DL-Trp
-
 Homo sapiens
1.13.11.52 2-methylindole
-
 Homo sapiens
1.13.11.52 5-hydroxy-L-Trp
-
 Homo sapiens
1.13.11.52 H2O2 at high concentrations Homo sapiens
1.13.11.52 N1-acetyl-N2-formyl-5-methoxykynurenine
-
 Homo sapiens
1.13.11.52 tryptamine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.043
-
 L-Trp
-
 Homo sapiens
1.13.11.52 5.2
-
 D-Trp
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 additional information Homo sapiens the oxidative metabolism of melatonin is due, in presence of H2O2, to the activities of both myeloperoxidase, EC 1.11.1.7 and indolemanine 2,3-dioxygenase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P48775
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52 recombinant enzyme Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.52 0.38
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-Trp + O2
-
 Homo sapiens D-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2
-
 Homo sapiens L-formylkynurenine
-
 ?
1.13.11.52 additional information the oxidative metabolism of melatonin is due, in presence of H2O2, to the activities of both myeloperoxidase, EC 1.11.1.7 and indolemanine 2,3-dioxygenase Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 indoleamine 2,3-dioxygenase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.023
-
 1-methyl-DL-Trp
-
 Homo sapiens
1.13.11.52 0.072
-
 5-hydroxy-L-Trp
-
 Homo sapiens
1.13.11.52 0.158
-
 2-methylindole
-
 Homo sapiens
1.13.11.52 0.255
-
 tryptamine
-
 Homo sapiens