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Literature summary extracted from

  • Veitch, N.J.; Maugeri, D.A.; Cazzulo, J.J.; Lindqvist, Y.; Barrett, M.P.
    Transketolase from Leishmania mexicana has a dual subcellular localization (2004), Biochem. J., 382, 759-767.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.2.1.1
-
 Leishmania mexicana

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.2.1.1
-
 Leishmania mexicana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.1 D-ribose-5-phosphate substrate inhibition above 50 mM Leishmania mexicana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.2.1.1 2.75
-
 D-ribose-5-phosphate pH 7.5 Leishmania mexicana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.2.1.1 cytosol predominantly cytosolic Leishmania mexicana 5829
-
2.2.1.1 glycosome significant part of total activity Leishmania mexicana 20015
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.2.1.1 70000
-
 crystallization data, 2 * 70000, SDS-PAGE, 2 * 71800, deduced from gene sequence Leishmania mexicana
2.2.1.1 71800
-
 crystallization data, 2 * 70000, SDS-PAGE, 2 * 71800, deduced from gene sequence Leishmania mexicana

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.1 Leishmania mexicana Q8MPM3 expression in Escherichia coli
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.2.1.1 proteolytic modification type-1 peroxisome targeting signal Leishmania mexicana

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.2.1.1 1.7
-
 pH 7.5 Leishmania mexicana

Storage Stability

EC Number Storage Stability Organism
2.2.1.1 -80°C, without glycerol, stable Leishmania mexicana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.1 D-xylulose 5-phosphate + D-ribose 5-phosphate
-
 Leishmania mexicana sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.2.1.1 dimer crystallization data, 2 * 70000, SDS-PAGE, 2 * 71800, deduced from gene sequence Leishmania mexicana

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.2.1.1 8.4
-
 D-ribose-5-phosphate pH 7.5 Leishmania mexicana