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Literature summary extracted from

  • Kern, A.; Szentpetery, Z.; Liliom, K.; Bakos, E.; Sarkadi, B.; Varadi, A.
    Nucleotides and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter (2004), Biochem. J., 380, 549-560.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 MRP1, expression in Sf9 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
7.6.2.2 additional information inactive MRP1 deletion mutant lacking residues 1-280 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 orthovanadate non-covalent inhibitor of ABC ATPases catalyzing a photo-oxidative cleavage, characterization of three cleavage sites within MRP1, influence of nucleotides and transported substrates on the cleavage reaction, mechanism Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 cell membrane membrane topology of MRP1 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.6.2.2 160000
-
 x * 160000, recombinant MRP1, domain structure, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Homo sapiens the ABC transporter MRP1 is involved in the cellular extrusion of conjugated metabolites and causes multidrug resistance in tumor cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
7.6.2.2 ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] mechanism Homo sapiens
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.6.2.2 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + etoposide/in
-
 Homo sapiens ADP + phosphate + etoposide/out
-
 ?
7.6.2.2 ATP + H2O + leukotriene C4/in
-
 Homo sapiens ADP + phosphate + leukotriene C4/out
-
 ?
7.6.2.2 ATP + H2O + N-ethylmaleimide S-glutathione/in
-
 Homo sapiens ADP + phosphate + N-ethylmaleimide S-glutathione/out
-
 ?
7.6.2.2 ATP + H2O + verapamil/in
-
 Homo sapiens ADP + phosphate + verapamil/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in mechanism, model of the MRP1 ATPase hydrolytic cycle, nucleotide-binding and MRP1 interaction with the transported substrates induce two different allosteric effects during the ATPase cycle, MRP1 domain structure Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 additional information the ABC transporter MRP1 is involved in the cellular extrusion of conjugated metabolites and causes multidrug resistance in tumor cells Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.2 ? x * 160000, recombinant MRP1, domain structure, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCC1
-
 Homo sapiens
7.6.2.2 MRP1
-
 Homo sapiens