EC Number | Cloned (Comment) | Organism |
---|---|---|
7.6.2.2 | MRP1, expression in Sf9 cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.6.2.2 | additional information | inactive MRP1 deletion mutant lacking residues 1-280 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | orthovanadate | non-covalent inhibitor of ABC ATPases catalyzing a photo-oxidative cleavage, characterization of three cleavage sites within MRP1, influence of nucleotides and transported substrates on the cleavage reaction, mechanism | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.2 | cell membrane | membrane topology of MRP1 | Homo sapiens | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | 160000 | - |
x * 160000, recombinant MRP1, domain structure, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | additional information | Homo sapiens | the ABC transporter MRP1 is involved in the cellular extrusion of conjugated metabolites and causes multidrug resistance in tumor cells | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
7.6.2.2 | ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] | mechanism | Homo sapiens |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + etoposide/in | - |
Homo sapiens | ADP + phosphate + etoposide/out | - |
? | |
7.6.2.2 | ATP + H2O + leukotriene C4/in | - |
Homo sapiens | ADP + phosphate + leukotriene C4/out | - |
? | |
7.6.2.2 | ATP + H2O + N-ethylmaleimide S-glutathione/in | - |
Homo sapiens | ADP + phosphate + N-ethylmaleimide S-glutathione/out | - |
? | |
7.6.2.2 | ATP + H2O + verapamil/in | - |
Homo sapiens | ADP + phosphate + verapamil/out | - |
? | |
7.6.2.2 | ATP + H2O + xenobiotic/in | mechanism, model of the MRP1 ATPase hydrolytic cycle, nucleotide-binding and MRP1 interaction with the transported substrates induce two different allosteric effects during the ATPase cycle, MRP1 domain structure | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
7.6.2.2 | additional information | the ABC transporter MRP1 is involved in the cellular extrusion of conjugated metabolites and causes multidrug resistance in tumor cells | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
7.6.2.2 | ? | x * 160000, recombinant MRP1, domain structure, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | ABCC1 | - |
Homo sapiens |
7.6.2.2 | MRP1 | - |
Homo sapiens |