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Literature summary extracted from

  • Vougier, S.; Mary, J.; Friguet, B.
    Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells (2003), Biochem. J., 373, 531-537.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 mitochondrial and cytosolic isozymes are encoded by a single gene Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 cytosol cytosolic isozyme of MsrA Rattus norvegicus 5829
-
1.8.4.11 mitochondrion matrix, mitochondrial isozyme of MsrA Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin Rattus norvegicus MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Rattus norvegicus
-
 2 isozymes of MsrA
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.8.4.11 proteolytic modification enzyme precursor contains a cleavable N-terminal signal sequence for targeting to the mitochondria Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.11 MsrA from cytosolic and mitochondrial fractions Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.11 0.0002
-
 cytosol, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide Rattus norvegicus
1.8.4.11 0.00021
-
 mitochondria, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine (S)-sulfoxide + thioredoxin synthetic substrate Rattus norvegicus dabsyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Rattus norvegicus protein-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues Rattus norvegicus protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulphoxide reductase A
-
 Rattus norvegicus
1.8.4.11 MsrA
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Rattus norvegicus