EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.21 | expression in Pichia pastoris | Ovis aries |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.21 | additional information | chimaera in which the distinctive N-terminal segmant of ovine m-BPT 1 is replaced with that from rat M-CPT 1. The ovine N-terminal segment influences the kinetics of the enzyme for both its substrates, such that the Km for palmitoyl-CoA is decreased and that for carnitine is increased for the chimera, relative to the parental enzyme M-CPT 1 from Ovis aries | Ovis aries |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.21 | malonyl-CoA | IC50 for wild-type L-CPT-1 is 0.0298 mM; IC50 for wild-type M-CPT-1 is 0.010 mM | Ovis aries |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.03 | - |
palmitoyl-CoA | chimaera in which the distinctive N-terminal segment of ovine m-BPT 1 is replaced with that from rat M-CPT 1 | Ovis aries | |
2.3.1.21 | 0.0374 | - |
palmitoyl-CoA | wild-type L-CPT1 | Ovis aries | |
2.3.1.21 | 0.0676 | - |
palmitoyl-CoA | wild-type M-CPT1 | Ovis aries | |
2.3.1.21 | 0.215 | - |
L-carnitine | wild-type L-CPT 1 | Ovis aries | |
2.3.1.21 | 0.56 | - |
L-carnitine | wild-type M-CPT 1 | Ovis aries | |
2.3.1.21 | 0.785 | - |
L-carnitine | chimaera in which the distinctive N-terminal segment of ovine m-BPT 1 is replaced with that from rat M-CPT 1 | Ovis aries |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.21 | Ovis aries | Q7YQR7 | - |
- |
2.3.1.21 | Ovis aries | Q8SPI7 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.21 | adipose tissue | - |
Ovis aries | - |
2.3.1.21 | brain | - |
Ovis aries | - |
2.3.1.21 | brain | high level of mRNA | Ovis aries | - |
2.3.1.21 | heart | - |
Ovis aries | - |
2.3.1.21 | heart | high level of mRNA | Ovis aries | - |
2.3.1.21 | kidney | - |
Ovis aries | - |
2.3.1.21 | kidney | high level of mRNA | Ovis aries | - |
2.3.1.21 | liver | - |
Ovis aries | - |
2.3.1.21 | liver | high level of mRNA | Ovis aries | - |
2.3.1.21 | lung | - |
Ovis aries | - |
2.3.1.21 | mammary gland | lactating, high level of mRNA | Ovis aries | - |
2.3.1.21 | mammary gland | non-lactating, high level of mRNA | Ovis aries | - |
2.3.1.21 | additional information | no activity in spleen | Ovis aries | - |
2.3.1.21 | pancreas | - |
Ovis aries | - |
2.3.1.21 | skeletal muscle | - |
Ovis aries | - |
2.3.1.21 | skeletal muscle | high level of mRNA | Ovis aries | - |
2.3.1.21 | spleen | - |
Ovis aries | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | palmitoyl-CoA + L-carnitine | - |
Ovis aries | CoA + L-palmitoylcarnitine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.21 | CPT1A | - |
Ovis aries |
2.3.1.21 | CPT1B | - |
Ovis aries |
2.3.1.21 | L-CPT 1 | - |
Ovis aries |
2.3.1.21 | M-CPT 1 | - |
Ovis aries |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.01 | - |
IC50 for wild-type M-CPT-1 is 0.010 mM | Ovis aries | malonyl-CoA | |
2.3.1.21 | 0.0298 | - |
IC50 for wild-type L-CPT-1 is 0.0298 mM | Ovis aries | malonyl-CoA |