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Literature summary extracted from

  • Aubol, B.E.; Reich, N.O.
    Murine DNA cytosine C(5)-methyltransferase: in vitro studies of de novo methylation spreading (2003), Biochem. Biophys. Res. Commun., 310, 209-214.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.37 5-methyl cytosine preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA Mus musculus
2.1.1.37 additional information no modulation of catalytic activity in response to 5-methyl cytosine Spirulina sp.

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Mus musculus P13864
-
-
2.1.1.37 Spirulina sp.
-
-
-
2.1.1.37 Spirulina sp. MW-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 S-adenosyl-L-methionine + DNA
-
 Spirulina sp. S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
2.1.1.37 S-adenosyl-L-methionine + DNA preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA Mus musculus S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
2.1.1.37 S-adenosyl-L-methionine + DNA
-
 Spirulina sp. MW-1 S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 DNA cytosine C(5)-methyltransferase
-
 Mus musculus
2.1.1.37 Dnmt1
-
 Mus musculus
2.1.1.37 M.SssI
-
 Spirulina sp.