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Literature summary extracted from

  • Polevoda, B.; Sherman, F.
    Composition and function of the eukaryotic N-terminal acetyltransferase subunits (2003), Biochem. Biophys. Res. Commun., 308, 1-11.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.255 27000
-
 x * 27000 (Ard1p) + x * 99000 (Nat1p), Ard1p is the catalytic subunit, Nat1p is the auxiliary subunit Saccharomyces cerevisiae
2.3.1.255 99000
-
 x * 27000 (Ard1p) + x * 99000 (Nat1p), Ard1p is the catalytic subunit, Nat1p is the auxiliary subunit Saccharomyces cerevisiae
2.3.1.256 10000
-
-
 Saccharomyces cerevisiae
2.3.1.256 20000
-
-
 Saccharomyces cerevisiae
2.3.1.256 84000
-
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.255 acetyl-CoA + peptide Saccharomyces cerevisiae NatA acetylation is important for function of a set of proteins involved in general groth control CoA + Nalpha-acetylpeptide
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] Saccharomyces cerevisiae
-
 an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] Saccharomyces cerevisiae
-
 an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] Saccharomyces cerevisiae
-
 an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] Saccharomyces cerevisiae
-
 an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Saccharomyces cerevisiae
-
-
-
2.3.1.256 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.255 acetyl-CoA + peptide NatA acetylation is important for function of a set of proteins involved in general groth control Saccharomyces cerevisiae CoA + Nalpha-acetylpeptide
-
 ?
2.3.1.255 acetyl-CoA + peptide acetylates N-terminal Ser, Ala, Gly or Thr residues Saccharomyces cerevisiae CoA + Nalpha-acetylpeptide
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein]
-
 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein]
-
 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein]
-
 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA
-
 ?
2.3.1.256 acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein]
-
 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.255 ? x * 27000 (Ard1p) + x * 99000 (Nat1p), Ard1p is the catalytic subunit, Nat1p is the auxiliary subunit Saccharomyces cerevisiae
2.3.1.256 heterotrimer 1 * 20000 + 1 * 84000 + 1 * 10000, subunit Mak3p, Mak10p and Mak31p, calculated from amino acid sequence Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 NatA
-
 Saccharomyces cerevisiae
2.3.1.256 MAK10 auxiliary subunit Saccharomyces cerevisiae
2.3.1.256 Mak31p auxiliary subunit Saccharomyces cerevisiae
2.3.1.256 Mak3p catalytic subunit Saccharomyces cerevisiae
2.3.1.256 NatC
-
 Saccharomyces cerevisiae