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Literature summary extracted from

  • Dai, J.; Zhu, H.; Woldegiorgis, G.
    Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity (2003), Biochem. Biophys. Res. Commun., 301, 758-763.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 mutant enzymes expressed in Pichia pastoris Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.21 DELTA563-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA659-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA728-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA752-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA762-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA763-772 mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity Homo sapiens
2.3.1.21 DELTA766-772 activity of the mutant is similar to wild-type enzyme Homo sapiens
2.3.1.21 DELTA769-772 activity of the mutant is similar to wild-type enzyme Homo sapiens
2.3.1.21 L264A 60.4% of the wild-type activity Homo sapiens
2.3.1.21 L764R 16.3% of the wild-type activity Homo sapiens
2.3.1.21 L764V as active as the wild-type enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 0.0448
-
 palmitoyl-CoA mutant enzyme L764R Homo sapiens
2.3.1.21 0.0466
-
 palmitoyl-CoA wild-type enzyme Homo sapiens
2.3.1.21 0.679
-
 L-carnitine wild-type enzyme Homo sapiens
2.3.1.21 1.588
-
 L-carnitine mutant enzyme L764R Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens Q92523
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyltransferase I
-
 Homo sapiens
2.3.1.21 M-CPTI
-
 Homo sapiens