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Literature summary extracted from
- Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain (2004), Arch. Toxicol., 78, 316-320.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.4 | Aroclor 1254 | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.4 | L-tryptophan + tetrahydropteridine + O2 | Rattus norvegicus | rate-limiting enzyme in synthesis of 5-hydroxy-L-tryptophan | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.4 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.4 | brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.4 | L-tryptophan + tetrahydropteridine + O2 | rate-limiting enzyme in synthesis of 5-hydroxy-L-tryptophan | Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.4 | TPH | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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