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Literature summary extracted from

  • Fu, J.; Yamamoto, K.; Guan, Z.W.; Kimura, S.; Iyanagi, T.
    Human neuronal nitric oxide synthase can catalyze one-electron reduction of adriamycin: role of flavin domain (2004), Arch. Biochem. Biophys., 427, 180-187.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.39 0.0073
-
 mitomycin C full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 0.01
-
 menadione FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 0.01
-
 menadione FAD-FMN domain, presence of calmodulin Homo sapiens
1.14.13.39 0.011
-
 menadione full-length enzyme, presence of calmodulin Homo sapiens
1.14.13.39 0.012
-
 adriamycin FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 0.013
-
 mitomycin C full-length enzyme, presence of calmodulin Homo sapiens
1.14.13.39 0.014
-
 menadione full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 0.015
-
 mitomycin C FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 0.021
-
 adriamycin full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 0.028
-
 mitomycin C FAD-NADPH domain Homo sapiens
1.14.13.39 0.041
-
 menadione FAD-NADPH domain Homo sapiens
1.14.13.39 0.043
-
 adriamycin full-length enzyme, presence of calmodulin Homo sapiens
1.14.13.39 0.05
-
 adriamycin FAD-NADPH domain Homo sapiens
1.14.13.39 0.055
-
 mitomycin C FAD-FMN domain, presence of calmodulin Homo sapiens
1.14.13.39 0.078
-
 adriamycin FAD-FMN domain, presence of calmodulin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Homo sapiens
-
 neuronal enzyme, full-length enzyme, FAD-FMN-domain, FAD-NADPH-domain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 adriamycin + NADPH + O2
-
 Homo sapiens ? + NO + NADP+
-
 ?
1.14.13.39 menadione + NADPH + O2
-
 Homo sapiens ? + NO + NADP+
-
 ?
1.14.13.39 mitomycin c + NADPH + O2
-
 Homo sapiens ? + NO + NADP+
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.13.39 0.62
-
 mitomycin C full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 0.8
-
 mitomycin C FAD-NADPH domain Homo sapiens
1.14.13.39 2.2
-
 mitomycin C FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 4.8
-
 adriamycin FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 4.9
-
 adriamycin FAD-NADPH domain Homo sapiens
1.14.13.39 5.3
-
 adriamycin full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 6.6
-
 menadione full-length enzyme, absence of calmodulin Homo sapiens
1.14.13.39 8
-
 menadione FAD-NADPH domain Homo sapiens
1.14.13.39 9.5
-
 menadione FAD-FMN domain, absence of calmodulin Homo sapiens
1.14.13.39 15.8
-
 mitomycin C full-length enzyme, presence of calmodulin Homo sapiens
1.14.13.39 26
-
 mitomycin C FAD-FMN domain, presence of calmodulin Homo sapiens
1.14.13.39 88
-
 menadione FAD-FMN domain, presence of calmodulin Homo sapiens
1.14.13.39 94
-
 adriamycin FAD-FMN domain, presence of calmodulin Homo sapiens
1.14.13.39 95
-
 adriamycin full-length enzyme, presence of calmodulin Homo sapiens
1.14.13.39 96
-
 menadione full-length enzyme, presence of calmodulin Homo sapiens