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Literature summary extracted from

  • Maligie, M.A.; Selitrennikoff, C.P.
    Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins (2005), Antimicrob. Agents Chemother., 49, 2851-2856.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.34 CaCl2 7 mM, 2fold increase in activity Cryptococcus neoformans
2.4.1.34 EDTA maximal activity at 50 mM Cryptococcus neoformans
2.4.1.34 MgCl2 5 mM, 3fold increase in activity Cryptococcus neoformans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.34 caspofungin 50% inhibition at 0.00013 mg/ml Aspergillus fumigatus
2.4.1.34 caspofungin 50% inhibition at 0.016 mg/ml Cryptococcus neoformans
2.4.1.34 caspofungin 50% inhibition at 0.004 mg/ml Neurospora crassa
2.4.1.34 caspofungin 50% inhibition at 0.00013 mg/ml Saccharomyces cerevisiae
2.4.1.34 cilofungin 50% inhibition at 0.064 mg/ml Cryptococcus neoformans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.34 additional information
-
additional information optimization of in vitro assay conditions Cryptococcus neoformans
2.4.1.34 0.21
-
UDP-glucose pH 7.75 Cryptococcus neoformans

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.34 Aspergillus fumigatus
-
-
-
2.4.1.34 Cryptococcus neoformans
-
-
-
2.4.1.34 Neurospora crassa
-
-
-
2.4.1.34 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.34 UDP-glucose + (1,3-beta-D-glucosyl)n
-
Saccharomyces cerevisiae UDP + (1,3-beta-D-glucosyl)n+1
-
?
2.4.1.34 UDP-glucose + (1,3-beta-D-glucosyl)n
-
Neurospora crassa UDP + (1,3-beta-D-glucosyl)n+1
-
?
2.4.1.34 UDP-glucose + (1,3-beta-D-glucosyl)n
-
Cryptococcus neoformans UDP + (1,3-beta-D-glucosyl)n+1
-
?
2.4.1.34 UDP-glucose + (1,3-beta-D-glucosyl)n
-
Aspergillus fumigatus UDP + (1,3-beta-D-glucosyl)n+1
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.34 7.75
-
-
Cryptococcus neoformans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.34 0.00017
-
caspofungin pH 7.75, 25°C Cryptococcus neoformans
2.4.1.34 0.00067
-
caspofungin pH 7.75, 25°C Saccharomyces cerevisiae
2.4.1.34 0.0022
-
caspofungin pH 7.75, 25°C Neurospora crassa
2.4.1.34 0.0041
-
caspofungin pH 7.75, 25°C Aspergillus fumigatus
2.4.1.34 0.022
-
cilofungin pH 7.75, 25°C Cryptococcus neoformans