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Literature summary extracted from

  • Jogl, G.; Hsiao, Y.S.; Tong, L.
    Structure and function of carnitine acyltransferases (2004), Ann. N. Y. Acad. Sci., 1033, 17-29.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.7 crystallized as pure enzyme and in complex with its substrates carnitine and CoA Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.137 R518N site-directed mutagenesis, mutant shows 1650fold increased Km for L-carnitine, only slightly affected Km for acyl-CoA and kcat compared to the wild-type enzyme Bos taurus
2.3.1.137 S552A site-directed mutagenesis, mutant shows 17fold increased Km for L-carnitine compared to the wild-type enzyme Bos taurus
2.3.1.137 S554X site-directed mutagenesis, mutant shows 10fold decreased kcat compared to the wild-type enzyme Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 membrane
-
Bos taurus 16020
-
2.3.1.137 mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Mus musculus modulates acetyl-CoA and CoA availability for a wide range of acyl-transfer reactions, involved in fatty acid metabolism CoA + O-acetylcarnitine
-
r
2.3.1.137 octanoyl-CoA + L-carnitine Bos taurus step in the transport of fatty acids across the inner mitochondrial membrane, reaction plays a role in balancing cellular CoA:acyl-CoA ratio CoA + L-octanoylcarnitine
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Mus musculus
-
-
-
2.3.1.137 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.7 acetyl-CoA + carnitine = CoA + O-acetylcarnitine reaction mechanism Mus musculus
2.3.1.137 octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine catalytic mechanism, active site structure, substrate recognition mechanism, amino acid residues 343, 564 and 553 determine the acyl-CoA substrate specificity, catalytic residue is His343 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
Mus musculus CoA + O-acetylcarnitine
-
r
2.3.1.7 acetyl-CoA + carnitine modulates acetyl-CoA and CoA availability for a wide range of acyl-transfer reactions, involved in fatty acid metabolism Mus musculus CoA + O-acetylcarnitine
-
r
2.3.1.137 octanoyl-CoA + L-carnitine step in the transport of fatty acids across the inner mitochondrial membrane, reaction plays a role in balancing cellular CoA:acyl-CoA ratio Bos taurus CoA + L-octanoylcarnitine
-
r
2.3.1.137 octanoyl-CoA + L-carnitine carnitine binding site structure involving the highly conserved R518, Y452 and T465, CoA binding site n the active site tunnel via His343, fatty acid binding site Bos taurus CoA + L-octanoylcarnitine
-
r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 carnitine octanoyltransferase
-
Bos taurus
2.3.1.137 CrOT
-
Bos taurus
2.3.1.137 More enzyme belongs to the family of carnitine acyltransferases Bos taurus