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Literature summary extracted from

  • Hakala, K.S.; Suchanova, B.; Luukkanen, L.; Ketola, R.A.; Finel, M.; Kostiainen, R.
    Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases (2005), Anal. Biochem., 341, 105-112.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information kinetics Homo sapiens
2.4.1.17 0.00048
-
 8-hydroxyquinoline isozyme UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.0065
-
 8-hydroxyquinoline isozyme UGT1A6, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.016
-
 8-hydroxyquinoline isozyme UGT2B15, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.021
-
 entacapone isozyme UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.111
-
 umbelliferone isozyme UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.115
-
 4-Methylumbelliferone isozyme UGT1A1, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.149
-
 4-Methylumbelliferone isozyme UGT2B15, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.157
-
 4-Methylumbelliferone isozyme UGT1A6, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.18
-
 4-Methylumbelliferone isozyme UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.294
-
 umbelliferone isozyme UGT1A1, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.294
-
 entacapone isozyme UGT1A3, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.301
-
 8-hydroxyquinoline isozyme UGT2B7, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.335
-
 4-Methylumbelliferone isozyme UGT1A3, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.339
-
 umbelliferone isozyme UGT2B15, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.494
-
 8-hydroxyquinoline isozyme UGT1A3, pH 7.4, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 isozyme UGT1A6
-
2.4.1.17 Homo sapiens O60656 isozyme UGT1A9; isozyme UGT1A9
-
2.4.1.17 Homo sapiens P16662 isozyme UGT2B7; isozyme UGT2B7
-
2.4.1.17 Homo sapiens P22309 isozyme UGT1A1; isozyme UGT1A1
-
2.4.1.17 Homo sapiens P35503 isozyme UGT1A3; isozyme UGT1A3
-
2.4.1.17 Homo sapiens P54855 isozyme UGT2B15; isozyme UGT2B15
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information substrate specificity of isozymes, overview Homo sapiens ?
-
 ?
2.4.1.17 UDP-glucuronate + 17beta-estriol
-
 Homo sapiens UDP + estriol 17-beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + 4-methylumbelliferone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 8-hydroxyquinoline
-
 Homo sapiens UDP + 8-hydroxyquinoline beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + entacapone
-
 Homo sapiens UDP + entacapone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + paracetamol
-
 Homo sapiens UDP + paracetamol beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + tolcapone
-
 Homo sapiens UDP + tolcapone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + umbelliferone
-
 Homo sapiens UDP + umbelliferone beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens