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Literature summary extracted from

  • Yan, Z.H.; Ren, K.J.; Wang, Y.; Chen, S.; Brock, T.A.; Rege, A.A.
    Development of intramolecularly quenched fluorescent peptides as substrates of angiotensin-converting enzyme 2 (2003), Anal. Biochem., 312, 141-147.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 Sf21 cells via infection with baculovirus, mIgG-tagged protein Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Cl- required, highest activity at 1.5 M NaCl Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin I + H2O Homo sapiens
-
 angiotensin-(1-9) + Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.17.23 recombinant from Sf21 cells as mIgG-tagged protein Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 RPPGSPF + H2O i.e. des-Arg-bradykinin Homo sapiens RPPGSP + Phe i.e. des-Arg-bradykinin-(1-7) ir
3.4.17.23 TBC5046 + H2O synthetic fluorogenic peptide, i.e. des-Arg-bradykinin with N-terminal o-aminobenzoic acid and a 3-nitrophenylalanine instead of Phe at the C-terminus Homo sapiens o-aminobenzoic acid-des-Arg-bradykinin-(1-7) + 3-nitrophenylalanine
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens
3.4.17.23 angiotensin-converting enzyme-related carboxypeptidase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.23 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.23 7
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.17.23 4.5 8 activity drops sharply at pH 8.0, substantial activity at pH 4.5-6.5, inactive at pH 9.0 Homo sapiens