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Literature summary extracted from

  • Moonen, M.J.H.; Fraaije, M.W.; Rietjens, I.M.C.M.; Laane, C.; Van Berkel, W.J.H.
    Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds (2002), Adv. Synth. Catal., 344, 1023-1035.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.64 3,5-Dichloro-4-hydroxybenzoate
-
Candida parapsilosis
1.14.13.64 4-Hydroxy-3,5-dinitrobenzoate
-
Candida parapsilosis
1.14.13.64 4-Hydroxyisophthalate
-
Candida parapsilosis
1.14.13.64 Cl-
-
Candida parapsilosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.13.64 50000
-
-
Candida parapsilosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.64 additional information Candida parapsilosis the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source ?
-
?
1.14.13.64 additional information Candida parapsilosis CBS604 the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.64 Candida parapsilosis
-
CBS604
-
1.14.13.64 Candida parapsilosis CBS604
-
CBS604
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.64 4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
-
Candida parapsilosis 2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
?
1.14.13.64 4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
-
Candida parapsilosis CBS604 2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
?
1.14.13.64 4-hydroxybenzoate + NADH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis hydroquinone + NAD+ + CO2
-
?
1.14.13.64 4-hydroxybenzoate + NADH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis CBS604 hydroquinone + NAD+ + CO2
-
?
1.14.13.64 4-hydroxybenzoate + NADPH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis hydroquinone + NADP+ + CO2
-
?
1.14.13.64 4-hydroxybenzoate + NADPH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis CBS604 hydroquinone + NADP+ + CO2
-
?
1.14.13.64 additional information the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source Candida parapsilosis ?
-
?
1.14.13.64 additional information the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring Candida parapsilosis ?
-
?
1.14.13.64 additional information the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source Candida parapsilosis CBS604 ?
-
?
1.14.13.64 additional information the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring Candida parapsilosis CBS604 ?
-
?
1.14.13.64 tetrafluoro-4-hydroxybenzoate + NAD(P)H + O2
-
Candida parapsilosis 2,3,5,6-tetrafluorohydroquinone + NAD(P)+ + CO2
-
?

Subunits

EC Number Subunits Comment Organism
1.14.13.64 monomer 1 * 50000 Candida parapsilosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.64 8
-
-
Candida parapsilosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.64 FAD dependent on Candida parapsilosis
1.14.13.64 NADH the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis
1.14.13.64 NADPH the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis