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Literature summary extracted from

  • Allegri, G.; Bertazzo, A.; Biasiolo, M.; Costa, C.V.; Ragazzi, E.
    Kynurenine pathway enzymes in different species of animals (2003), Adv. Exp. Med. Biol., 527, 455-463.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.9 mitochondrion
-
 Cavia porcellus 5739
-
1.14.13.9 mitochondrion
-
 Mus musculus 5739
-
1.14.13.9 mitochondrion
-
 Rattus norvegicus 5739
-
1.14.13.9 mitochondrion
-
 Oryctolagus cuniculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + O2 Cavia porcellus enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 Mus musculus enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 Rattus norvegicus enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 Oryctolagus cuniculus enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Cavia porcellus
-
 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Mus musculus
-
 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Oryctolagus cuniculus
-
 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Cavia porcellus L-tryptophan metabolism anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Mus musculus L-tryptophan metabolism anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Rattus norvegicus L-tryptophan metabolism anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Oryctolagus cuniculus L-tryptophan metabolism anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Cavia porcellus
-
-
-
1.14.13.9 Mus musculus
-
-
-
1.14.13.9 Oryctolagus cuniculus
-
-
-
1.14.13.9 Rattus norvegicus
-
-
-
3.7.1.3 Cavia porcellus
-
-
-
3.7.1.3 Mus musculus
-
-
-
3.7.1.3 Oryctolagus cuniculus
-
-
-
3.7.1.3 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.7.1.3 no modification
-
 Cavia porcellus
3.7.1.3 no modification
-
 Mus musculus
3.7.1.3 no modification
-
 Rattus norvegicus
3.7.1.3 no modification
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 kidney
-
 Cavia porcellus
-
1.14.13.9 kidney
-
 Mus musculus
-
1.14.13.9 kidney
-
 Rattus norvegicus
-
1.14.13.9 kidney
-
 Oryctolagus cuniculus
-
1.14.13.9 liver
-
 Cavia porcellus
-
1.14.13.9 liver
-
 Mus musculus
-
1.14.13.9 liver
-
 Rattus norvegicus
-
1.14.13.9 liver
-
 Oryctolagus cuniculus
-
3.7.1.3 kidney
-
 Cavia porcellus
-
3.7.1.3 kidney
-
 Mus musculus
-
3.7.1.3 kidney
-
 Rattus norvegicus
-
3.7.1.3 kidney
-
 Oryctolagus cuniculus
-
3.7.1.3 liver
-
 Cavia porcellus
-
3.7.1.3 liver
-
 Mus musculus
-
3.7.1.3 liver
-
 Rattus norvegicus
-
3.7.1.3 liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.9 0.0005
-
 kidney Oryctolagus cuniculus
1.14.13.9 0.001
-
 liver Oryctolagus cuniculus
1.14.13.9 0.0015
-
 activity in liver and in kidney Cavia porcellus
1.14.13.9 0.0022
-
 liver Rattus norvegicus
1.14.13.9 0.0025
-
 liver Mus musculus
1.14.13.9 0.0025
-
 kidney Rattus norvegicus
1.14.13.9 0.004
-
 kidney Mus musculus
3.7.1.3 0.00001
-
 kidney, approximately Mus musculus
3.7.1.3 0.00003
-
 liver, kidney, approximate values Oryctolagus cuniculus
3.7.1.3 0.00004
-
 liver, approximately Mus musculus
3.7.1.3 0.00006
-
 liver, kidney, approximate values Rattus norvegicus
3.7.1.3 0.00009
-
 liver, kidney, approximate values Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + O2
-
 Cavia porcellus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2
-
 Mus musculus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2
-
 Oryctolagus cuniculus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview Cavia porcellus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview Mus musculus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
1.14.13.9 L-kynurenine + NADPH + O2 enzyme is involved in L-tryptophan catabolism, pathway regulation in comparison to other species, overview Oryctolagus cuniculus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Cavia porcellus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Mus musculus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Oryctolagus cuniculus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O L-tryptophan metabolism Cavia porcellus anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O L-tryptophan metabolism Mus musculus anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O L-tryptophan metabolism Rattus norvegicus anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O L-tryptophan metabolism Oryctolagus cuniculus anthranilate + L-alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.9 L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating)
-
 Cavia porcellus
1.14.13.9 L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating)
-
 Mus musculus
1.14.13.9 L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating)
-
 Rattus norvegicus
1.14.13.9 L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating)
-
 Oryctolagus cuniculus
3.7.1.3 L-kynurenine hydrolase
-
 Cavia porcellus
3.7.1.3 L-kynurenine hydrolase
-
 Mus musculus
3.7.1.3 L-kynurenine hydrolase
-
 Rattus norvegicus
3.7.1.3 L-kynurenine hydrolase
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.9 NADPH
-
 Cavia porcellus
1.14.13.9 NADPH
-
 Mus musculus
1.14.13.9 NADPH
-
 Rattus norvegicus
1.14.13.9 NADPH
-
 Oryctolagus cuniculus