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Literature summary extracted from

  • Kayser, O.; Chen, M.; Kharazmi, A.; Kiderlen, A.F.
    Aurones interfere with Leishmania major mitochondrial fumarate reductase (2002), Z. Naturforsch. C, 57c, 717-720.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.3.1.6 medicine aurones and auronols can be used as antiprotozoal compounds because the kill intracellularly persisting amastigozyte of Leishmania major by inhibiting respiratory function of parasite mitochondria Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 2',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 3',4',6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 3',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 4',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 4,6,3'-hydroxy-4'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 4,6,4'-hydroxy-3'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 4,6,4'-triacetyl-3',5'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one i.e. bracteintriacetate Leishmania major
1.3.1.6 4,6-dihydroxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
 Leishmania major
1.3.1.6 6-benzoyl-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
 Leishmania major
1.3.1.6 6-hydroxy-2-[(2,3,4-trihydroxyphenyl)-methylene]-3(2H)-benzofuran-3-one-5-beta-D-glucopyranoside i.e. bractein Leishmania major
1.3.1.6 6-hydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 6-hydroxy-3',4'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 6-hydroxy-benzofuran-3-one
-
 Leishmania major
1.3.1.6 6-methoxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
1.3.1.6 additional information inhibitory potency of aurones and auronols, overview Leishmania major

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.6 mitochondrion
-
 Leishmania major 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Leishmania major
-
 succinate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Leishmania major
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.6 partially, preparation of the mitochondrial fraction Leishmania major

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Leishmania major succinate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.6 FRD
-
 Leishmania major
1.3.1.6 fumarate reductase
-
 Leishmania major
1.3.1.6 NADH-FRD
-
 Leishmania major

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Leishmania major