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Literature summary extracted from

  • DuTeaux, S.B.; Newman, J.W.; Morisseau, C.; Fairbairn, E.A.; Jelks, K.; Hammock, B.D.; Miller, M.G.
    Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism (2004), Toxicol. Sci., 78, 187-195.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.3.2.10 additional information the enzyme is induced by clofibrate in liver not in epididymis Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 membrane
-
 Rattus norvegicus 16020
-
3.3.2.9 microsome
-
 Rattus norvegicus
-
-
3.3.2.10 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.9 50000
-
 x * 50000, SDS-PAGE Rattus norvegicus
3.3.2.10 65000
-
 x * 65000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.10 11,12-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
 11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 14,15-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
 14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 5,6-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
 5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 8,9-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
 8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information Rattus norvegicus the enzyme is involved in the arachidonic acid metabolic pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Rattus norvegicus
-
-
-
3.3.2.10 Rattus norvegicus
-
 male Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 epididymis caput, corpus, cauda Rattus norvegicus
-
3.3.2.9 kidney
-
 Rattus norvegicus
-
3.3.2.9 liver
-
 Rattus norvegicus
-
3.3.2.9 spermatid
-
 Rattus norvegicus
-
3.3.2.9 testis
-
 Rattus norvegicus
-
3.3.2.10 epididymis caput, corpus, cauda Rattus norvegicus
-
3.3.2.10 kidney
-
 Rattus norvegicus
-
3.3.2.10 liver
-
 Rattus norvegicus
-
3.3.2.10 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.3.2.9 0.00019
-
 epididymis microsomes Rattus norvegicus
3.3.2.9 0.00051
-
 testis microsomes Rattus norvegicus
3.3.2.9 0.0057
-
 liver microsomes Rattus norvegicus
3.3.2.10 0.00051
-
 epididymis cytosol Rattus norvegicus
3.3.2.10 0.001
-
 liver cytosol Rattus norvegicus
3.3.2.10 0.0027
-
 kidney cytosol Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 cis-stilbene oxide + H2O
-
 Rattus norvegicus (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?
3.3.2.10 11,12-epoxyeicosatrienoic acid + H2O
-
 Rattus norvegicus 11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 14,15-epoxyeicosatrienoic acid + H2O
-
 Rattus norvegicus 14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 5,6-epoxyeicosatrienoic acid + H2O
-
 Rattus norvegicus 5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 8,9-epoxyeicosatrienoic acid + H2O
-
 Rattus norvegicus 8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information the enzyme is involved in the arachidonic acid metabolic pathway Rattus norvegicus ?
-
 ?
3.3.2.10 trans-diphenylpropene oxide + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.3.2.9 ? x * 50000, SDS-PAGE Rattus norvegicus
3.3.2.10 ? x * 65000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.3.2.9 mEH
-
 Rattus norvegicus
3.3.2.10 SEH
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.3.2.10 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.10 7.4
-
 assay at Rattus norvegicus