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Literature summary extracted from

  • Wallin, R.; Sane, D.C.; Hutson, S.M.
    Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system (2003), Thromb. Res., 108, 221-226.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome
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 Rattus norvegicus
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol Rattus norvegicus vitamin K is an essential cofactor for post-translational gamma-carboxylation of vitamin K-dependent coagulation factors. The modification is carried out by a system of integral proteins of the endoplasmic reticulum membrane where the warfarin sensitive vitamin K 2,3-epoxide reductase (VKOR) produces the reduced hydroquinone form of vitamin K needed by the gamma-carboxylase as the active cofactor. VKOR is the rate-limiting step in the system vitamin K1 + oxidized dithiothreitol
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Rattus norvegicus
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol vitamin K is an essential cofactor for post-translational gamma-carboxylation of vitamin K-dependent coagulation factors. The modification is carried out by a system of integral proteins of the endoplasmic reticulum membrane where the warfarin sensitive vitamin K 2,3-epoxide reductase (VKOR) produces the reduced hydroquinone form of vitamin K needed by the gamma-carboxylase as the active cofactor. VKOR is the rate-limiting step in the system Rattus norvegicus vitamin K1 + oxidized dithiothreitol
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 VKOR
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 Rattus norvegicus
1.17.4.4 warfarin sensitive vitamin K 2,3-epoxide reductase
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 Rattus norvegicus