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Literature summary extracted from

  • Pauly, T.A.; Ekstrom, J.L.; Beebe, D.A.; Chrunyk, B.; Cunningham, D.; Griffor, M.; Kamath, A.; Lee, S.E.; Madura, R.; McGuire, D.; Subashi, T.; Wasilko, D.; Watts, P.; Mylari, B.L.; Oates, P.J.; Adams, P.D.; Rath, V.L.
    X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase (2003), Structure, 11, 1071-1085.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.14 purified enzyme alone, and in complex with NAD+, or with NADH and inhibitor SDI-158, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution, modelling Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.14 2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine i.e. SDI-158 or CP-166,572 Homo sapiens
1.1.1.14 2-methyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine i.e. SDI-157 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.14 Zn2+ the catalytic zinc is coordinated with residues His69, Cys44, Glu70, and a water molecule Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.14 D-sorbitol + NAD+ Homo sapiens part of the polyol pathway that interconverts glucose and fructose L-sorbose + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.14 Homo sapiens Q00796
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.14 D-sorbitol + NAD+
-
 Homo sapiens L-sorbose + NADH + H+
-
 ?
1.1.1.14 D-sorbitol + NAD+ part of the polyol pathway that interconverts glucose and fructose Homo sapiens L-sorbose + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.14 tetramer 4 identical, catalytically active subunits, crystal structure Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.14 SDH
-
 Homo sapiens
1.1.1.14 sorbitol dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.14 NAD+
-
 Homo sapiens