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Literature summary extracted from

  • Nobel, C.S.I.; Dunas, F.; Abrahmsen, L.B.
    Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities (2002), Protein Expr. Purif., 26, 349-356.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 expression in Pichia pastoris Rattus norvegicus
1.1.1.146 expression Pichia pastoris Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.0006
-
 cortisone 37°C, pH 7.4, recombinant 11beta-HSD1 Homo sapiens
1.1.1.146 0.0017
-
 cortisol 37°C, pH 7.4, recombinant 11beta-HSD1 Homo sapiens
1.1.1.146 0.0025
-
 11-Dehydrocorticosterone 37°C, pH 7.4, recombinant 11beta-HSD1 Rattus norvegicus
1.1.1.146 0.003
-
 corticosterone 37°C, pH 7.4, recombinant 11beta-HSD1 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.146 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
1.1.1.146 membrane attached to the membrane facing the luminal compartment Homo sapiens 16020
-
1.1.1.146 membrane attached to the membrane facing the luminal compartment Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 corticosterone + NADP+ Rattus norvegicus bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo 11-dehydrocorticosterone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+ Homo sapiens bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.146 glycoprotein
-
 Homo sapiens
1.1.1.146 glycoprotein
-
 Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.146
-
 Homo sapiens
1.1.1.146
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 liver
-
 Homo sapiens
-
1.1.1.146 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 corticosterone + NADP+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADPH + H+
-
 r
1.1.1.146 corticosterone + NADP+ bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo Rattus norvegicus 11-dehydrocorticosterone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 r
1.1.1.146 cortisone + NADPH + H+ bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo Homo sapiens cortisol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-HSD1
-
 Rattus norvegicus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus