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Literature summary extracted from
- Prostaglandin E2 9-keto reductase activity in bovine retained and not retained placenta (2002), Prostaglandins Leukot. Essent. Fatty Acids, 66, 413-417.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.189 | prostaglandin E2 + NADPH | Bos taurus | key enzyme responsible for the control of prostaglandin levels in placental tissues | prostaglandin F2alpha + NADP+ | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.189 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.189 | placenta | with and without retained fetal membranes, retained and not retained tissue, activity increases with parturition, activity is higher in the maternal than in the fetal part, overview | Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | additional information | - |
activities in retained and not retained placenta samples from different animal groups | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.189 | prostaglandin E2 + NADPH | broad substrate specificity | Bos taurus | prostaglandin F2alpha + NADP+ | - |
r | |
| 1.1.1.189 | prostaglandin E2 + NADPH | key enzyme responsible for the control of prostaglandin levels in placental tissues | Bos taurus | prostaglandin F2alpha + NADP+ | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.189 | 9-KPR | - |
Bos taurus |
| 1.1.1.189 | prostaglandin-E2 9-keto reductase | - |
Bos taurus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | 37 | - |
assay at | Bos taurus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.189 | 7.4 | - |
assay at | Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.189 | NADP+ | - |
Bos taurus | |
| 1.1.1.189 | NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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