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Literature summary extracted from

  • Cho, H.; Tai, H.H.
    Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents (2002), Prostaglandins, 67, 461-465.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.141 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 15-deoxy-DELTA12,14-prostaglandin J2 0.024 mM, 50% inhibition Homo sapiens
1.1.1.141 Berberine 0.023 mM, 50% inhibition Homo sapiens
1.1.1.141 Biochanin A 0.031 mM, 50% inhibition Homo sapiens
1.1.1.141 chalcone 0.016 mM, 50% inhibition Homo sapiens
1.1.1.141 chrysin 0.021 mM, 50% inhibition Homo sapiens
1.1.1.141 ciglitazone 0.003 mM, 50% inhibition Homo sapiens
1.1.1.141 curcumin 0.01 mM, 50% inhibition Homo sapiens
1.1.1.141 DuP 697 0.022 mM, 50% inhibition Homo sapiens
1.1.1.141 epigallocatechin gallate 0.012 mM, 50% inhibition Homo sapiens
1.1.1.141 Flufenamic acid 0.041 mM, 50% inhibition Homo sapiens
1.1.1.141 flurbiprofen 0.062 mM, 50% inhibition Homo sapiens
1.1.1.141 indomethacin 0.066 mM, 50% inhibition Homo sapiens
1.1.1.141 ketorolac 0.028 mM, 50% inhibition Homo sapiens
1.1.1.141 Meclofenamic acid 0.073 mM, 50% inhibition Homo sapiens
1.1.1.141 Mefenamic acid 0.076 mM, 50% inhibition Homo sapiens
1.1.1.141 MK 886 0.037 mM, 50% inhibition Homo sapiens
1.1.1.141 N-(2-phenylethyl)-indomethacin amide 0.098 mM, 50% inhibition Homo sapiens
1.1.1.141 N-(3-pyridyl)-indomethacin amide 0.1 mM, 50% inhibition Homo sapiens
1.1.1.141 niflumic acid 0.058 mM, 50% inhibition Homo sapiens
1.1.1.141 nimesulide 0.051 mM, 50% inhibition Homo sapiens
1.1.1.141 NS 398 0.064 mM, 50% inhibition Homo sapiens
1.1.1.141 resveratrol 0.054 mM, 50% inhibition Homo sapiens
1.1.1.141 rosiglitazone 0.026 mM, 50% inhibition Homo sapiens
1.1.1.141 sulindac 0.041 mM, 50% inhibition Homo sapiens
1.1.1.141 sulindac sulfide 0.018 mM, 50% inhibition Homo sapiens
1.1.1.141 sulindac sulfone 0.038 mM, 50% inhibition Homo sapiens
1.1.1.141 troglitazone 0.34 mM, 50% inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.141 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141 recombinant 15-PGDH Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 NAD+-dependent 15-PGDH
-
 Homo sapiens