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Literature summary extracted from

  • Binda, C.; Li, M.; Hubalek, F.; Restelli, N.; Edmondson, D.E.; Mattevi, A.
    Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures (2003), Proc. Natl. Acad. Sci. USA, 100, 9750-9755.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.4 sitting-drop vapour diffusion method,1.7 A structure of the reversible isatin-MAO-B complex, 2.3 A structure of the 1,4-diphenyl-2-butene-MAO-B complex, 2.2 A structure of the tranylcypromine-MAO B complex, 2.4 A structure of the N-(2-aminoethyl)-p-chlorobenzamide-MAO-B complex, 3.1 A structure of the lauryldimethylamine N-oxide-MAO-B complex Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 1,4-diphenyl-2-butene inhibits by covalent binding to the flavin ring, reversible inhibitor of MAO-B Homo sapiens
1.4.3.4 isatin
-
 Homo sapiens
1.4.3.4 N-(2-aminoethyl)-p-chlorobenzamide inhibits by covalent binding to the flavin ring Homo sapiens
1.4.3.4 trans-2-phenylcyclopropylamine inhibits by covalent binding to the flavin ring Homo sapiens
1.4.3.4 trans-trans-1,4-diphenyl-1,3-butadiene
-
 Homo sapiens
1.4.3.4 tranylcypromine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-B
-
 Homo sapiens
1.4.3.4 monoamine oxidase B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.003
-
 isatin
-
 Homo sapiens
1.4.3.4 0.007
-
 trans-trans-1,4-diphenyl-1,3-butadiene
-
 Homo sapiens