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Literature summary extracted from

  • Stepansky, A.; Galili, G.
    Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals (2003), Plant Physiol., 133, 1407-1415.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Arabidopsis sp. the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Arabidopsis sp. the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level L-Glu + 2-aminoadipate 6-semialdehyde + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.8 Arabidopsis sp.
-
 ecotype C-24
-
1.5.1.9 Arabidopsis sp.
-
 ecotype C-24
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH
-
 Arabidopsis sp. N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level Arabidopsis sp. N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Arabidopsis sp. L-Glu + 2-aminoadipate 6-semialdehyde + NADH
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level Arabidopsis sp. L-Glu + 2-aminoadipate 6-semialdehyde + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.8 LKR/SDH
-
 Arabidopsis sp.
1.5.1.8 lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional Arabidopsis sp.
1.5.1.9 LKR/SDH
-
 Arabidopsis sp.
1.5.1.9 lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional Arabidopsis sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.8 NADPH
-
 Arabidopsis sp.
1.5.1.9 NAD+
-
 Arabidopsis sp.