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Literature summary extracted from
- HPLC-based bioactivity profiling of plant extracts: a kinetic assay for the identification of monoamine oxidase-A inhibitors using human recombinant monoamine oxidase-A (2004), Phytochemistry, 65, 2885-2891.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | analysis | kinetic assay for detection of MAO-A inhibitors in plant extracts using recombinant MAO-A expressed as GST-fusion protein in yesat | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.4.3.4 | monoamine oxidase A is cloned into the high copy yeast expression vector pEG-KT, to generate a GST MAO-A fusion protein | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | Clorgyline | IC50: 0.000014 mM | Homo sapiens |  |
| 1.4.3.4 | Deprenyl | IC50: 0.020 mM | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.15 | - |
kynuramine | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.4.3.4 | 65000 | - |
x * 65000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | liver | - |
Homo sapiens | - |
| 1.4.3.4 | placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.4 | kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | ? | x * 65000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | MAO-A | - |
Homo sapiens |
| 1.4.3.4 | monoamine oxidase A | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.000014 | - |
IC50: 0.000014 mM | Homo sapiens | Clorgyline | |
| 1.4.3.4 | 0.02 | - |
IC50: 0.020 mM | Homo sapiens | Deprenyl | |
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Release 2023.1 (January 2023)
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