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Literature summary extracted from

  • Blaser, A.; Reymond, J.L.
    Stereoselective inhibition of alpha-L-fucosidases by N-benzyl aminocyclopentitols (2000), Org. Lett., 2, 1733-1736.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.51 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Bos taurus
3.2.1.51 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Fusarium oxysporum
3.2.1.51 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Homo sapiens
3.2.1.51 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Bos taurus
3.2.1.51 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Fusarium oxysporum
3.2.1.51 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
-
 Homo sapiens
3.2.1.51 (R)-2-aminobutanol
-
 Bos taurus
3.2.1.51 (R)-2-aminobutanol
-
 Fusarium oxysporum
3.2.1.51 (R)-2-aminobutanol
-
 Homo sapiens
3.2.1.51 (S)-2-aminobutanol
-
 Bos taurus
3.2.1.51 (S)-2-aminobutanol
-
 Fusarium oxysporum
3.2.1.51 (S)-2-aminobutanol
-
 Homo sapiens
3.2.1.51 alpha-L-fuco-N-benzyl aminocyclopentitol
-
 Bos taurus
3.2.1.51 alpha-L-fuco-N-benzyl aminocyclopentitol
-
 Fusarium oxysporum
3.2.1.51 alpha-L-fuco-N-benzyl aminocyclopentitol
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.51 0.25
-
 p-nitrophenyl alpha-L-fucoside pH 6.8, 25°C Homo sapiens
3.2.1.51 0.33
-
 p-nitrophenyl alpha-L-fucoside pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 0.75
-
 p-nitrophenyl alpha-L-fucoside pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 0.75
-
 p-nitrophenyl alpha-L-fucoside pH 6.8, 25°C, kidney Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.51 Bos taurus
-
-
-
3.2.1.51 Fusarium oxysporum
-
-
-
3.2.1.51 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.51 epididymis
-
 Bos taurus
-
3.2.1.51 kidney
-
 Bos taurus
-
3.2.1.51 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.51 p-nitrophenyl alpha-L-fucoside + H2O
-
 Homo sapiens p-nitrophenol + alpha-L-fucose
-
 ?
3.2.1.51 p-nitrophenyl alpha-L-fucoside + H2O
-
 Bos taurus p-nitrophenol + alpha-L-fucose
-
 ?
3.2.1.51 p-nitrophenyl alpha-L-fucoside + H2O
-
 Fusarium oxysporum p-nitrophenol + alpha-L-fucose
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.51 0.3
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C Homo sapiens
3.2.1.51 0.57
-
 alpha-L-fuco N-benzyl aminocyclopentitol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 0.68
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 6
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 12
-
 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 14
-
 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C Homo sapiens
3.2.1.51 15
-
 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 18
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C Homo sapiens
3.2.1.51 22
-
 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C Homo sapiens
3.2.1.51 28
-
 alpha-L-fuco N-benzyl aminocyclopentitol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 28
-
 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 58
-
 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 100
-
 (S)-2-aminobutanol pH 6.8, 25°C Homo sapiens
3.2.1.51 110
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 125
-
 (1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 125
-
 (S)-2-aminobuthanol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 180
-
 alpha-L-fuco-N-benzyl aminocyclopentitol pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 188
-
 (1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 200
-
 (R)-2-aminobutanol pH 6.8, 25°C Homo sapiens
3.2.1.51 200
-
 (S)-2-aminobutanol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 350
-
 (R)-2-aminobuthanol pH 6.8, 25°C, epididymis Bos taurus
3.2.1.51 400
-
 (R)-2-aminobutanol pH 6.8, 25°C, kidney Bos taurus
3.2.1.51 1100
-
 (R)-2-aminobutanol pH 6.8, 25°C Fusarium oxysporum
3.2.1.51 1300
-
 (S)-2-aminobutanol pH 6.8, 25°C Fusarium oxysporum