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Literature summary extracted from
- Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation (2002), Mutat. Res., 509, 221-226.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.25.1 | medicine | application of the enzyme packaged in an engineered liposome delivery vehicle to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, it traverses the stratum corneum, reaches the nuclei of living skin cells, and enhances the repair of UV-induced cyclobutane pyrimidine dimers | Tequatrovirus T4 |
| 3.1.25.1 | molecular biology | UV-induced cell damage in xeroderma pigmentosa cells can be repaired by properly delivered T4 endonuclease V and can be used as a model for investigation of DNA repair, mutagenesis, and cell signaling without manipulation of the genome | Tequatrovirus T4 |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.25.1 | DNA + H2O | Tequatrovirus T4 | application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.25.1 | Tequatrovirus T4 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.25.1 | DNA + H2O | application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview | Tequatrovirus T4 | ? | - |
? | |
| 3.1.25.1 | DNA + H2O | excision of pyrimidine dimers produced within duplex DNA by UV radiation | Tequatrovirus T4 | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.25.1 | T4 endonuclease V | - |
Tequatrovirus T4 |
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Release 2023.1 (January 2023)
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