Literature summary extracted from

Chang, K.C.; Paek, K.S.; Kim, H.J.; Lee, Y.S.; Yabe-Nishimura, C.; Seo, H.G.
Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes (2002), Mol. Pharmacol., 61, 1184-1191.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.21	methylglyoxal	up to 4.5fold induction of mRNA, activity and protein level, abolished in presence of cycloheximide or actinomycin D	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.21	additional information	Rattus norvegicus	protective role of enzyme against methylglyoxal induced cell damage	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.21	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.21	muscle	aortic smooth muscle cell	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.21	additional information	protective role of enzyme against methylglyoxal induced cell damage	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)