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Literature summary extracted from

  • Guo, S.; Bhattacharjee, J.K.
    Site-directed mutational analysis of the novel catalytic domains of alpha-aminoadipate reductase (Lys2p) from Candida albicans (2003), Mol. Genet. Genomics, 269, 271-279.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.95 mutant enzymes expressed in Escherichia coli BL21 Candida albicans

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.95 A459G 106% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 A475G 109% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 A979G 94% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 D461E 4% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 D461N no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 D466E 15% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 E420T 101% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F415Y 71% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F452L 6% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F452V 45% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F468L 96% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F982L 4% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 F982V no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 G418A 31% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G418V no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 G421A 75% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G425A 99% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G474A 41% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G978A 2% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G978S no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 G981A no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 G981V no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 G984A 3% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 G984S no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 H460R no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 I422V 92% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 I463L no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 I987V 92% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 K424R 26% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 K424T 3% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 K451Q 58% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 K451R no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 K535Q 94% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 L446I 71% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 L471V 89% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 L983V 31% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 M440L 99% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 P423V 51% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 P462A 2% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 P462S no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 Q464E 17% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 Q511E 31% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 Q511L 129% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 R465K 2% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 R465S no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 S417A 10% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 S417T 82% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 S419A 16% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 S419T no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 S456T 59% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 S985A 85% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T416A no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 T416S 35% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T469S 80% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T506A 49% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T506S no alpha-aminoadipate reductase activity Candida albicans
1.2.1.95 T534A 103% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T977S 70% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 T980S 28% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 V426L 64% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans
1.2.1.95 V529I 117% of the alpha-aminoadipate reductase activity of wild-type enzyme Candida albicans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.95 MgCl2 required Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.95 Candida albicans Q12572
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.95 (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate presence of ATP and Mg2+ required Candida albicans L-2-aminoadipate + NADPH + H+ + ATP
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.95 alpha-aminoadipate reductase
-
Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.95 NADPH
-
Candida albicans