Literature summary extracted from
Giordano, E.; Peluso, I.; Rendina, R.; Digilio, A.; Furia, M.
The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily (2003), Mol. Genet. Genomics, 268, 692-697.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
1.5.4.1 |
2-mercaptoethanol |
required for the in vitro assay |
Drosophila melanogaster |
|
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.5.4.1 |
DNA and amino acid sequence determination and analysis |
Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
1.5.4.1 |
6-pyruvoyl-tetrahydropterin + glutathione |
Drosophila melanogaster |
essential step in the biosynthesis of red components of the flye's eye pigments drosopterins |
pyrimidodiazepine + glutathione disulfide |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.5.4.1 |
Drosophila melanogaster |
Q9VMQ9 |
gene clot |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
1.5.4.1 |
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione |
active site contains the sequence Cys-Pro-Tyr-Cys |
Drosophila melanogaster |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.5.4.1 |
6-pyruvoyl-tetrahydropterin + glutathione |
- |
Drosophila melanogaster |
pyrimidodiazepine + glutathione disulfide |
- |
? |
|
1.5.4.1 |
6-pyruvoyl-tetrahydropterin + glutathione |
essential step in the biosynthesis of red components of the flye's eye pigments drosopterins |
Drosophila melanogaster |
pyrimidodiazepine + glutathione disulfide |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.5.4.1 |
More |
enzyme belongs to the thioredoxin-like protein superfamily |
Drosophila melanogaster |