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Literature summary extracted from

  • Anbalagan, M.; Yashwanth, R.; Jagannadha Rao, A.
    DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis (2004), Mol. Cell. Endocrinol., 219, 37-45.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.21 diagnostics enzyme is a key marker of early Leydig cell steroidogenesis, using the technique of differential display RT-PCR Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.21 analysis of differentially expressed transcripts of gene dhcr7 in progenitor Leydig cells and in immature Leydig cells, increased expression of the enzyme during differentiation process Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.21 additional information analysis of physiological effects of immunoneutralization of the enzyme in Leydig cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH Rattus norvegicus
-
 cholesterol + NADP+
-
 ?
1.3.1.21 additional information Rattus norvegicus enzyme is essential for steroidogenesis, enzyme is not regulated by the luteinizing hormone LH ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.21 Leydig cell progenitor cells, immature cells, and adult cells, differentially expressed transcripts and enzyme expression levels during development and differentiation, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH
-
 Rattus norvegicus cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH i.e. 7-dehydrocholesterol Rattus norvegicus cholesterol + NADP+
-
 ?
1.3.1.21 additional information enzyme is essential for steroidogenesis, enzyme is not regulated by the luteinizing hormone LH Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Rattus norvegicus