Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zamore, P.D.
    Thirty-three years later, a glimpse at the ribonuclease III active site (2001), Mol. Cell, 8, 1158-1160.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.26.3 Mg2+ divalent metal ion requirement for catalysis Drosophila melanogaster
3.1.26.3 Mg2+ divalent metal ion requirement for catalysis Escherichia coli
3.1.26.3 Mg2+ divalent metal ion requirement for catalysis Homo sapiens
3.1.26.3 Mg2+ divalent metal ion requirement for catalysis Arabidopsis thaliana
3.1.26.3 Mg2+ divalent metal ion requirement for catalysis Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.26.3 dsRNA + H2O Aquifex aeolicus reshaping of fully or partially double-stranded RNA precursors in to mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing mature RNA
-
 ?
3.1.26.3 dsRNA + H2O Drosophila melanogaster reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing mature RNA
-
 ?
3.1.26.3 dsRNA + H2O Escherichia coli reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing mature RNA
-
 ?
3.1.26.3 dsRNA + H2O Homo sapiens reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing mature RNA
-
 ?
3.1.26.3 dsRNA + H2O Arabidopsis thaliana reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing, enzyme is required for the orderly progression of plant development and for the defense of eukaryotic parasitic DNA and viruses mature RNA
-
 ?
3.1.26.3 dsRNA + H2O Caenorhabditis elegans reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing, enzyme is required for the orderly progression of plant development and for the defense of eukaryotic parasitic DNA and viruses mature RNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.3 Aquifex aeolicus
-
 prokaryotic RNases III are class I enzymes containing a single endonuclease domain linked to a double-stranded RNA binding domain
-
3.1.26.3 Arabidopsis thaliana
-
 Dicer, a class III RNase III containing an N-terminal ATP-dependent RNA helicase domain, a PAZ motif, and 2 C-terminal endonuclease domains followed by a single dsRNA binding domain
-
3.1.26.3 Caenorhabditis elegans
-
 Dicer, a class III RNase III containing an N-terminal ATP-dependent RNA helicase domain, a PAZ motif, and 2 C-terminal endonuclease domains followed by a single dsRNA binding domain
-
3.1.26.3 Drosophila melanogaster
-
 Dicer, a class III RNase III containing an N-terminal ATP-dependent RNA helicase domain, a PAZ motif, and 2 C-terminal endonuclease domains followed by a single dsRNA binding domain
-
3.1.26.3 Escherichia coli
-
 prokaryotic RNases III are class I enzymes containing a single endonuclease domain linked to a double-stranded RNA binding domain
-
3.1.26.3 Homo sapiens
-
 Dicer, a class III RNase III containing an N-terminal ATP-dependent RNA helicase domain, a PAZ motif, and 2 C-terminal endonuclease domains followed by a single dsRNA binding domain
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview Drosophila melanogaster
a
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview Escherichia coli
a
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview Homo sapiens
a
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview Arabidopsis thaliana
a
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview Caenorhabditis elegans
a
3.1.26.3 Endonucleolytic cleavage to a 5'-phosphomonoester catalytic active site and substrate binding site structure and number determines the classification into classes I to III, overview, mechanism Aquifex aeolicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors in to mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing Aquifex aeolicus mature RNA
-
 ?
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing Drosophila melanogaster mature RNA
-
 ?
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing Escherichia coli mature RNA
-
 ?
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing Homo sapiens mature RNA
-
 ?
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing, enzyme is required for the orderly progression of plant development and for the defense of eukaryotic parasitic DNA and viruses Arabidopsis thaliana mature RNA
-
 ?
3.1.26.3 dsRNA + H2O reshaping of fully or partially double-stranded RNA precursors into mature RNAs involved in pre-mRNA splicing, RNA modification, translation, gene silencing, and regulation of developmental timing, enzyme is required for the orderly progression of plant development and for the defense of eukaryotic parasitic DNA and viruses Caenorhabditis elegans mature RNA
-
 ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modificatin of rRNAs, and individual mRNAs, whose expression they regulate Escherichia coli mature RNA staggered breaks with 2 nt, 3'-overhanging ends and 5'-phosphate and 3'-hydroxy termini ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modificatin of rRNAs, and individual mRNAs, whose expression they regulate Homo sapiens mature RNA staggered breaks with 2 nt, 3'-overhanging ends and 5'-phosphate and 3'-hydroxy termini ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modification of rRNAs, and individual mRNAs, whose expression they regulate Arabidopsis thaliana mature RNA
-
 ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modification of rRNAs, and individual mRNAs, whose expression they regulate Drosophila melanogaster mature RNA staggered breaks with 2 nt, 3'-overhanging ends and 5'-phosphate and 3'-hydroxy termini ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modification of rRNAs, and individual mRNAs, whose expression they regulate Caenorhabditis elegans mature RNA staggered breaks with 2 nt, 3'-overhanging ends and 5'-phosphate and 3'-hydroxy termini ?
3.1.26.3 dsRNA + H2O cleavage of fully or partially double-stranded RNA precursors into mature structural and catalytic RNAs such as the snRNAs that splice pre-mRNA, rRNAs, and tRNAs that function in translation, swnoRNAs that guide modification of rRNAs, and individual mRNAs, whose expression they regulate Aquifex aeolicus mature RNA staggered breaks with 2 nt, 3'-overhanging ends and 5'-phosphate and 3'-hydroxy termini ?
3.1.26.3 additional information specificity for A-form dsRNA, enzyme is loosely associated with ribosomes Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.26.3 More model of class I endonuclease domain dimer Escherichia coli
3.1.26.3 More model of class I endonuclease domain dimer Aquifex aeolicus
3.1.26.3 More model of class III endonuclease domain dimer Drosophila melanogaster
3.1.26.3 More model of class III endonuclease domain dimer Homo sapiens
3.1.26.3 More model of class III endonuclease domain dimer Arabidopsis thaliana
3.1.26.3 More model of class III endonuclease domain dimer Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
3.1.26.3 Dicer
-
 Drosophila melanogaster
3.1.26.3 Dicer
-
 Escherichia coli
3.1.26.3 Dicer
-
 Homo sapiens
3.1.26.3 Dicer
-
 Arabidopsis thaliana
3.1.26.3 Dicer
-
 Aquifex aeolicus
3.1.26.3 ribonuclease D
-
 Aquifex aeolicus
3.1.26.3 RNase D
-
 Aquifex aeolicus
3.1.26.3 RNase III
-
 Drosophila melanogaster
3.1.26.3 RNase III
-
 Escherichia coli
3.1.26.3 RNase III
-
 Homo sapiens
3.1.26.3 RNase III
-
 Arabidopsis thaliana
3.1.26.3 RNase III
-
 Aquifex aeolicus
3.1.26.3 RNase O
-
 Aquifex aeolicus