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Literature summary extracted from
- Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil-DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats (2003), Med. Sci. Monit., 9, 16-24.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.2.15 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.2.15 | hypoxanthine-containing DNA + H2O | Rattus norvegicus | incision activity is increased with age above 12 months of the Wistar and OXYS rats, relation to content of free radicals, overview | hypoxanthine + DNA | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.2.15 | Rattus norvegicus | - |
Wistar rats and OXYS rats, the latter showing inherited overgeneration of free radicals | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.2.2.15 | partially, preparation of mitochondria from liver | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.2.15 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.2.2.15 | additional information | - |
activity at different ages of both rat races | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.2.15 | hypoxanthine-containing DNA + H2O | incision activity is increased with age above 12 months of the Wistar and OXYS rats, relation to content of free radicals, overview | Rattus norvegicus | hypoxanthine + DNA | - |
? | |
| 3.2.2.15 | hypoxanthine-containing oligodeoxynucleotide + H2O | synthetic mismatched substrate, hyopxanthine-removing, incision activity | Rattus norvegicus | hypoxanthine + oligodeoxynucleotide | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.2.15 | deoxyribonucleic acid glycosylase | - |
Rattus norvegicus |
| 3.2.2.15 | DNA(hypoxanthine) glycohydrolase | - |
Rattus norvegicus |
| 3.2.2.15 | hypoxanthine DNA glycosylase | - |
Rattus norvegicus |
| 3.2.2.15 | hypoxanthine-DNA glycosylase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.2.2.15 | 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.2.15 | 7.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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