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Literature summary extracted from

  • Steckelbroeck, S.; Watzka, M.; Reissinger, A.; Wegener-Toper, P.; Bidlingmaier, F.; Bliesener, N.; Hans, V.H.; Clusmann, H.; Ludwig, M.; Siekmann, L.; Klingmuller, D.
    Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain (2003), J. Steroid Biochem. Mol. Biol., 86, 79-92.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.62 0.003
-
 NADPH
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.62 cytoplasm
-
 Homo sapiens 5737
-
1.1.1.62 membrane isoforms 4 and 10 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 estradiol-17beta + NAD+ Homo sapiens
-
 estrone + NADH
-
 ?
1.1.1.62 estrone + NADPH + H+ Homo sapiens final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain estradiol-17beta + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
 isoforms 4, 5, 7, 8, 10, and 11, 17beta-HSD 4, 5, 7, 8, 10, and 11
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.62 17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ isoforms differs in substrate specificity and tissue distribution, some enzyme forms displays also other activities such as type 4 that acts also as a short chain alcohol dehydrogenase and hydratase and type 10, that is identical to endoplasmic amyloid-beta-binding protein and mitochondrial short chain L-3-hydroxyacyl-CoA dehydrogenase Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 adrenal cortex
-
 Homo sapiens
-
1.1.1.62 brain
-
 Homo sapiens
-
1.1.1.62 cardiac muscle low level Homo sapiens
-
1.1.1.62 liver high activity Homo sapiens
-
1.1.1.62 placenta isoform 8 is highly expressed, low level of isoform 5 Homo sapiens
-
1.1.1.62 prostate
-
 Homo sapiens
-
1.1.1.62 temporal lobe
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 androst-4-ene-3,17-dione + NADPH
-
 Homo sapiens androst-4-ene-17beta-ol-3-one + NADP+
-
 ?
1.1.1.62 estradiol-17beta + NAD+
-
 Homo sapiens estrone + NADH
-
 ?
1.1.1.62 estrone + NADPH + H+
-
 Homo sapiens estradiol-17beta + NADP+
-
 ?
1.1.1.62 estrone + NADPH + H+ final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain Homo sapiens estradiol-17beta + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.62 6.5 9 estrone reduction Homo sapiens
1.1.1.62 9
-
 estradiol-17beta oxidation Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.62 5 9.5 estrone reduction Homo sapiens
1.1.1.62 7.5 9.5 estradiol-17beta oxidation Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NAD+ oxidation Homo sapiens
1.1.1.62 NADPH reduction Homo sapiens