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Literature summary extracted from

  • Raynaud, J.P.; Cousse, H.; Martin, P.M.
    Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon (2002), J. Steroid Biochem. Mol. Biol., 82, 233-239.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 docosanol isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 lauric acid isoform 1, 50% inhibition at 0.0167 mM, isoform 2, 50% inhibition at 0.0186 mM Homo sapiens
1.3.1.22 lauric acid ethyl ester isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 linoleic acid isoform 1, 50% inhibition at 0.013 mM, isoform 2, 50% inhibition at 0.035 mM Homo sapiens
1.3.1.22 myristic acid isoform 2, 50% inhibition at 0.004 mM Homo sapiens
1.3.1.22 oleic acid isoform 1, 50% inhibition at 0.004 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 oleic acid ethyl ester isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 palmitic acid isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 sitosterol isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 stearic acid isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens
1.3.1.22 tocopherol isoform 1, 50% inhibition above 0.1 mM, isoform 2, 50% inhibition above 0.1 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
 recombinant isoforms 1 and 2, expressed in baculoviral system
-

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 5.5
-
 assay at, isoform 2 Homo sapiens
1.3.1.22 7.4
-
 assay at, isoform 1 Homo sapiens