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Literature summary extracted from

  • Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
    Estrogen metabolism in human colorectal cancer cells (2002), J. Steroid Biochem. Mol. Biol., 81, 281-289.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.62 vitamin D3 activates oxidative activity in HCT8 and LoVo cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 vitamin D3 inhibits reductive activity in HCT8 and LoVo cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 4-androstene-3,17-dione + NADPH + H+ Homo sapiens 17beta-HSD3 and 5, formation of active androgens in testis and prostate testosterone + NADP+
-
 ?
1.1.1.62 estradiol-17beta + NADP+ Homo sapiens 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity estrone + NADPH
-
 ?
1.1.1.62 estrone + NADPH + H+ Homo sapiens 17beta-HSD1, final step in the synthesis of active estrogens estradiol-17beta + NADP+
-
 ?
1.1.1.62 testosterone + NADP+ Homo sapiens 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens 4-androstene-3,17-dione + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
 isoforms 1-4, 17beta-HSD 1-4
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.62 17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ 5 isoforms with different substrate specificities and tissue distribution, 17beta-HSD1 predominantly catalyzes the reaction of estrone to estradiol-17beta, 17beta-HSD2 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD3 and 5 catalyzes the reaction of androstenedione to testosterone, 17beta-HSD4 catalyzes the reaction of estradiol-17beta to estrone with low substrate affinty Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 colorectal cancer cell
-
 Homo sapiens
-
1.1.1.62 DLD-1 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
1.1.1.62 HCT-116 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
1.1.1.62 HCT-8 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
1.1.1.62 LoVo cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 4-androstene-3,17-dione + NADPH + H+ 17beta-HSD3 and 5, formation of active androgens in testis and prostate Homo sapiens testosterone + NADP+
-
 ?
1.1.1.62 estradiol-17beta + NADP+ 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity Homo sapiens estrone + NADPH
-
 ?
1.1.1.62 estradiol-17beta + NADP+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estrone + NADPH
-
 ?
1.1.1.62 estrone + NADPH + H+ 17beta-HSD1, final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NADP+
-
 ?
1.1.1.62 estrone + NADPH + H+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estradiol-17beta + NADP+
-
 ?
1.1.1.62 testosterone + NADP+ 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens Homo sapiens 4-androstene-3,17-dione + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NADP+
-
 Homo sapiens
1.1.1.62 NADPH
-
 Homo sapiens