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Literature summary extracted from

  • Gao, C.Q.; Dhooge, W.S.; Kaufman, J.M.; Weyne, J.J.; Eechaute, W.P.
    Hypothalamic 5alpha-reductase and 3alpha-oxidoreductase activity in the male rat (2002), J. Steroid Biochem. Mol. Biol., 80, 91-98.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ Rattus norvegicus
-
 5alpha-pregnan-3,20-dione + NADPH + H+
-
 r
1.1.1.50 3alpha-hydroxypregn-4-en-20-one + NADP+ Rattus norvegicus
-
 pregn-4-en-3,20-dione + NADPH + H+
-
 ?
1.1.1.50 additional information Rattus norvegicus the high 3alpha-oxidoreductase activity in the hypothalamus of prepubertal rats is not related to the gonadal or adrenal steroids, the products are found in both prepubertal, mature, and castrated rats, rats with adrenalectomy show elevated enzyme activities, 3alpha-hydroxy progesterone is not related to the regulation of gonadotropin secretion in the male rat ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus
-
 male rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 hypothalamus
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.50 additional information
-
 age-dependent activities in vivo Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 3alpha,5alpha,20alpha-trihydroxyprogesterone + NADP+
-
 Rattus norvegicus 5alpha,20alpha-dihydroxyprogesterone-3-one + NADPH + H+
-
 r
1.1.1.50 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 Rattus norvegicus 5alpha-pregnan-3,20-dione + NADPH + H+
-
 r
1.1.1.50 3alpha-hydroxypregn-4-en-20-one + NADP+
-
 Rattus norvegicus pregn-4-en-3,20-dione + NADPH + H+
-
 ?
1.1.1.50 additional information the high 3alpha-oxidoreductase activity in the hypothalamus of prepubertal rats is not related to the gonadal or adrenal steroids, the products are found in both prepubertal, mature, and castrated rats, rats with adrenalectomy show elevated enzyme activities, 3alpha-hydroxy progesterone is not related to the regulation of gonadotropin secretion in the male rat Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 3alpha-OR
-
 Rattus norvegicus
1.1.1.50 3alpha-oxidoreductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.50 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.50 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADP+
-
 Rattus norvegicus
1.1.1.50 NADPH
-
 Rattus norvegicus