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Literature summary extracted from

  • Newman, S.P.; Purohit, A.; Ghilchik, M.W.; Potter, B.V.L.; Reed, M.J.
    Regulation of steroid sulphatase expression and activity in breast cancer (2000), J. Steroid Biochem. Mol. Biol., 75, 259-264.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.6.2 interleukin 6 plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability Homo sapiens
3.1.6.2 Tumor necrosis factor alpha plus interleucin 6, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.2 2.4 kb STS cDNA, expression in MCF-7 and COS-1 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 2-methoxyestrone-3-O-sulfamate potent active site-directed inhibitor, no effect on STS mRNA expression in fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 additional information Homo sapiens the action of STS makes a major contribution to the in situ estrogen production in breast tumors ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
 women
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 breast fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression Homo sapiens
-
3.1.6.2 breast cancer cell expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues Homo sapiens
-
3.1.6.2 fibroblast from normal and malignant breast tissue, study of the regulation of STS mRNA expression, expression in fibroblasts derived from breast tissue proximal to tumors, breast tumor tissue and reduction mammoplasty tissue, effect of menopausal status Homo sapiens
-
3.1.6.2 MCF-7 cell breast cancer cells, study of the regulation of STS mRNA expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 additional information the action of STS makes a major contribution to the in situ estrogen production in breast tumors Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 STS
-
 Homo sapiens