BRENDA - Enzyme Database show

Regulation of steroid sulphatase expression and activity in breast cancer

Newman, S.P.; Purohit, A.; Ghilchik, M.W.; Potter, B.V.L.; Reed, M.J.; J. Steroid Biochem. Mol. Biol. 75, 259-264 (2000)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.6.2
interleukin 6
plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
Homo sapiens
3.1.6.2
Tumor necrosis factor alpha
plus interleucin 6, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
3.1.6.2
2.4 kb STS cDNA, expression in MCF-7 and COS-1 cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
2-methoxyestrone-3-O-sulfamate
potent active site-directed inhibitor, no effect on STS mRNA expression in fibroblasts
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
additional information
Homo sapiens
the action of STS makes a major contribution to the in situ estrogen production in breast tumors
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.6.2
Homo sapiens
-
women
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast
fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression
Homo sapiens
-
3.1.6.2
breast cancer cell
expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues
Homo sapiens
-
3.1.6.2
fibroblast
from normal and malignant breast tissue, study of the regulation of STS mRNA expression, expression in fibroblasts derived from breast tissue proximal to tumors, breast tumor tissue and reduction mammoplasty tissue, effect of menopausal status
Homo sapiens
-
3.1.6.2
MCF-7 cell
breast cancer cells, study of the regulation of STS mRNA expression
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
656640
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
additional information
the action of STS makes a major contribution to the in situ estrogen production in breast tumors
656640
Homo sapiens
?
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.6.2
interleukin 6
plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
Homo sapiens
3.1.6.2
Tumor necrosis factor alpha
plus interleucin 6, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.6.2
2.4 kb STS cDNA, expression in MCF-7 and COS-1 cells
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
2-methoxyestrone-3-O-sulfamate
potent active site-directed inhibitor, no effect on STS mRNA expression in fibroblasts
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
additional information
Homo sapiens
the action of STS makes a major contribution to the in situ estrogen production in breast tumors
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast
fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression
Homo sapiens
-
3.1.6.2
breast cancer cell
expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues
Homo sapiens
-
3.1.6.2
fibroblast
from normal and malignant breast tissue, study of the regulation of STS mRNA expression, expression in fibroblasts derived from breast tissue proximal to tumors, breast tumor tissue and reduction mammoplasty tissue, effect of menopausal status
Homo sapiens
-
3.1.6.2
MCF-7 cell
breast cancer cells, study of the regulation of STS mRNA expression
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
656640
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
additional information
the action of STS makes a major contribution to the in situ estrogen production in breast tumors
656640
Homo sapiens
?
-
-
-
-