EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.6.2 | pharmacology | inhibition of STS is an important target for the development of new drugs for oncology and immunology | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.6.2 | 4-methylcoumarin-7-O-sulfamate | - |
Rattus norvegicus | |
3.1.6.2 | 4-oxo-2,3-dihydro-1H-cyclopenta-[c][1]benzopyran-7-O-sulfamate | 665 COUMATE, placental IC50: 200 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-7,8,9,10,11,12,13,14,15,16-decahydro-cyclododeca-[c][1]benzopyran-3-O-sulfamate | 6612 COUMATE, placental IC50: 60 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-7,8,9,10,11,12,13,14-octahydro-cyclodeca-[c][1]benzopyran-3-O-sulfamate | 6610 COUMATE, placental IC50: 1 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-7,8,9,10,11,12-hexahydro-cycloocta-[c][1]benzopyran-3-O-sulfamate | 668 COUMATE, placental IC50: 30 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-7,8,9,10-tetrahydro-dibenzo[b,d]pyran-3-O-sulfamate | 666 COUMATE, placental IC50: 70 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-8,9,10,11,12,13,14,15,16,17,18,19-dodecahydro-7H-cyclopentadeca-[c][1]benzopyran-3-O-sulfamate | 6615 COUMATE, placental IC50: 370 nM, most potent tricyclic coumarin sulfamate inhibitor tested in vivo | Rattus norvegicus | |
3.1.6.2 | 6-oxo-8,9,10,11,12,13,14,15,16,17-decahydro-7H-cyclotrideca-[c][1]benzopyran-3-O-sulfamate | 6613 COUMATE, placental IC50: 75 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-8,9,10,11,12,13,14,15-octahydro-7H-cycloundeca-[c][1]benzopyran-3-O-sulfamate | 6611 COUMATE, placental IC50: 13 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-8,9,10,11,12,13-hexahydro-7H-cyclonona-[c][1]benzopyran-3-O-sulfamate | 669 COUMATE, placental IC50: 2.4 nM | Rattus norvegicus | |
3.1.6.2 | 6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-[c][1]benzopyran-3-O-sulfamate | 667 COUMATE, placental IC50: 8 nM | Rattus norvegicus | |
3.1.6.2 | tricyclic coumarin sulfamate | in vitro and in vivo inhibition studies with E1-STS from different tissues, structure-activity relationship of a number of tricyclic coumarin sulfamates, the size of the third ring has a marked effect on inhibitor potency | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.6.2 | microsome | placental | Rattus norvegicus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.6.2 | Rattus norvegicus | - |
female Wistar rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.6.2 | brain | - |
Rattus norvegicus | - |
3.1.6.2 | liver | - |
Rattus norvegicus | - |
3.1.6.2 | placenta | - |
Rattus norvegicus | - |
3.1.6.2 | white blood cell | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.6.2 | estrone sulfate + H2O | - |
Rattus norvegicus | estrone + sulfate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.6.2 | E1-STS | - |
Rattus norvegicus |
3.1.6.2 | oestrone sulfatase | - |
Rattus norvegicus |
3.1.6.2 | STS | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.1.6.2 | 0.000001 | - |
6610 COUMATE, placental IC50: 1 nM | Rattus norvegicus | 6-oxo-7,8,9,10,11,12,13,14-octahydro-cyclodeca-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.0000024 | - |
669 COUMATE, placental IC50: 2.4 nM | Rattus norvegicus | 6-oxo-8,9,10,11,12,13-hexahydro-7H-cyclonona-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.000008 | - |
667 COUMATE, placental IC50: 8 nM | Rattus norvegicus | 6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.000013 | - |
6611 COUMATE, placental IC50: 13 nM | Rattus norvegicus | 6-oxo-8,9,10,11,12,13,14,15-octahydro-7H-cycloundeca-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.00003 | - |
668 COUMATE, placental IC50: 30 nM | Rattus norvegicus | 6-oxo-7,8,9,10,11,12-hexahydro-cycloocta-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.00006 | - |
6612 COUMATE, placental IC50: 60 nM | Rattus norvegicus | 6-oxo-7,8,9,10,11,12,13,14,15,16-decahydro-cyclododeca-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.00007 | - |
666 COUMATE, placental IC50: 70 nM | Rattus norvegicus | 6-oxo-7,8,9,10-tetrahydro-dibenzo[b,d]pyran-3-O-sulfamate | |
3.1.6.2 | 0.000075 | - |
6613 COUMATE, placental IC50: 75 nM | Rattus norvegicus | 6-oxo-8,9,10,11,12,13,14,15,16,17-decahydro-7H-cyclotrideca-[c][1]benzopyran-3-O-sulfamate | |
3.1.6.2 | 0.0002 | - |
665 COUMATE, placental IC50: 200 nM | Rattus norvegicus | 4-oxo-2,3-dihydro-1H-cyclopenta-[c][1]benzopyran-7-O-sulfamate | |
3.1.6.2 | 0.00037 | - |
6615 COUMATE, placental IC50: 370 nM, most potent tricyclic coumarin sulfamate inhibitor tested in vivo | Rattus norvegicus | 6-oxo-8,9,10,11,12,13,14,15,16,17,18,19-dodecahydro-7H-cyclopentadeca-[c][1]benzopyran-3-O-sulfamate |