EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.2 | ADP | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus | |
1.2.4.2 | carbonyl cyanide p-trifluoromethoxyphenylhydrazone | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus | |
1.2.4.2 | rotenone | stimulates H2O2 production | Mus musculus | |
1.2.4.2 | rotenone | stimulates H2O2 production | Rattus norvegicus | |
1.2.4.2 | thiamine diphosphate | exogenous | Mus musculus | |
1.2.4.2 | thiamine diphosphate | exogenous | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.4.2 | additional information | knock-out mice, deficient in dihydrolipoyl dehydrogenase, show reduced 2-oxoglutarate dehydrogenase activity and reduced H2O2 production | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.4.2 | mitochondrial inner membrane | - |
Mus musculus | 5743 | - |
1.2.4.2 | mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
1.2.4.2 | mitochondrion | - |
Mus musculus | 5739 | - |
1.2.4.2 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.2 | Ca2+ | - |
Mus musculus | |
1.2.4.2 | Ca2+ | - |
Rattus norvegicus | |
1.2.4.2 | Mg2+ | - |
Mus musculus | |
1.2.4.2 | Mg2+ | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.2 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Mus musculus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.4.2 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Rattus norvegicus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.4.2 | additional information | Mus musculus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? | |
1.2.4.2 | additional information | Rattus norvegicus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.2 | Mus musculus | - |
wild-type mice, and knock-out mice deficient in dihydrolipoyl dehydrogenase | - |
1.2.4.2 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.2 | brain | - |
Mus musculus | - |
1.2.4.2 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.2 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Mus musculus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.4.2 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
1.2.4.2 | additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Mus musculus | ? | - |
? | |
1.2.4.2 | additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.4.2 | alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Mus musculus |
1.2.4.2 | alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Rattus norvegicus |
1.2.4.2 | KGDHC | - |
Mus musculus |
1.2.4.2 | KGDHC | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.4.2 | 37 | - |
assay at, H2O2 production | Mus musculus |
1.2.4.2 | 37 | - |
assay at, H2O2 production | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.4.2 | 7.4 | - |
assay at | Mus musculus |
1.2.4.2 | 7.4 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.2 | NAD+ | - |
Mus musculus | |
1.2.4.2 | NAD+ | - |
Rattus norvegicus | |
1.2.4.2 | thiamine diphosphate | - |
Mus musculus | |
1.2.4.2 | thiamine diphosphate | - |
Rattus norvegicus |