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Literature summary extracted from

  • Starkov, A.A.; Fiskum, G.; Chinopoulos, C.; Lorenzo, B.J.; Browne, S.E.; Patel, M.S.; Beal, M.F.
    Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species (2004), J. Neurosci., 24, 7779-7788.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.2 ADP activates the enzyme complex for production of reactive oxygen species in absence of NAD+ Rattus norvegicus
1.2.4.2 carbonyl cyanide p-trifluoromethoxyphenylhydrazone activates the enzyme complex for production of reactive oxygen species in absence of NAD+ Rattus norvegicus
1.2.4.2 rotenone stimulates H2O2 production Mus musculus
1.2.4.2 rotenone stimulates H2O2 production Rattus norvegicus
1.2.4.2 thiamine diphosphate exogenous Mus musculus
1.2.4.2 thiamine diphosphate exogenous Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.2.4.2 additional information knock-out mice, deficient in dihydrolipoyl dehydrogenase, show reduced 2-oxoglutarate dehydrogenase activity and reduced H2O2 production Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.2 mitochondrial inner membrane
-
Mus musculus 5743
-
1.2.4.2 mitochondrial inner membrane
-
Rattus norvegicus 5743
-
1.2.4.2 mitochondrion
-
Mus musculus 5739
-
1.2.4.2 mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.4.2 Ca2+
-
Mus musculus
1.2.4.2 Ca2+
-
Rattus norvegicus
1.2.4.2 Mg2+
-
Mus musculus
1.2.4.2 Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Mus musculus
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Rattus norvegicus
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 additional information Mus musculus enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview ?
-
?
1.2.4.2 additional information Rattus norvegicus enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.2 Mus musculus
-
wild-type mice, and knock-out mice deficient in dihydrolipoyl dehydrogenase
-
1.2.4.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.2 brain
-
Mus musculus
-
1.2.4.2 brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Mus musculus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 additional information enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview Mus musculus ?
-
?
1.2.4.2 additional information enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.2 alpha-ketoglutarate dehydrogenase multienzyme complex
-
Mus musculus
1.2.4.2 alpha-ketoglutarate dehydrogenase multienzyme complex
-
Rattus norvegicus
1.2.4.2 KGDHC
-
Mus musculus
1.2.4.2 KGDHC
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.4.2 37
-
assay at, H2O2 production Mus musculus
1.2.4.2 37
-
assay at, H2O2 production Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.4.2 7.4
-
assay at Mus musculus
1.2.4.2 7.4
-
assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.2 NAD+
-
Mus musculus
1.2.4.2 NAD+
-
Rattus norvegicus
1.2.4.2 thiamine diphosphate
-
Mus musculus
1.2.4.2 thiamine diphosphate
-
Rattus norvegicus