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Literature summary extracted from

  • Murphy, T.C.; Amarnath, V.; Gibson, K.M.; Picklo, M.J., Sr.
    Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A) (2003), J. Neurochem., 86, 298-305.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.24
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 0.0035
-
 succinate semialdehyde recombinant enzyme Rattus norvegicus
1.2.1.24 0.0503
-
 4-hydroxy-trans-2-nonenal recombinant enzyme Rattus norvegicus
1.2.1.24 0.0589
-
 trans-2-hexenal recombinant enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.24 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.24 50000
-
 x * 50000, SDS-PAGE Rattus norvegicus
1.2.1.24 54430
-
 x * 54430, MALDI-MS Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.24 4-hydroxy-trans-2-nonenal + NAD+ Rattus norvegicus elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 4-hydroxy-trans-2-nonenal + NAD+ elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria Rattus norvegicus ?
-
 ?
1.2.1.24 4-hydroxy-trans-2-nonenal + NAD+ + H2O
-
 Rattus norvegicus 4-hydroxy-trans-2-nonenoate + NADH + H+
-
 ?
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Rattus norvegicus succinate + NADH + H+
-
 ?
1.2.1.24 trans-2-hexenal + NAD+ + H2O
-
 Rattus norvegicus trans-2-hexenoate + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.24 ? x * 50000, SDS-PAGE Rattus norvegicus
1.2.1.24 ? x * 54430, MALDI-MS Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.24 SSADH
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 NAD+
-
 Rattus norvegicus