Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kim, C.H.
    Catalytic domain of Salmonella typhimurium 2-oxoglutarate dehydrogenase is localized in N-terminal region (2003), J. Mol. Catal. B, 26, 193-200.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.4.2 gene ogdh, library screening, complementation of an enzyme-deficient Escherichia coli mutant strain JRG72, DNA and amino acid sequence determination and analysis, functional expression of full-length enzyme and N-terminal catalytic domain in Escherichia coli strain JM109 Salmonella enterica subsp. enterica serovar Typhimurium

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.2 mitochondrion
-
 Salmonella enterica subsp. enterica serovar Typhimurium 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.4.2 30000
-
 x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
1.2.4.2 110000
-
 x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Salmonella enterica subsp. enterica serovar Typhimurium
-
 [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.2 Salmonella enterica subsp. enterica serovar Typhimurium O87668 strain ATCC 14028, gene ogdh, enzyme E1o is a component of the 2-oxoglutarate dehydrogenase multienzyme complex
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Salmonella enterica subsp. enterica serovar Typhimurium [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ir

Subunits

EC Number Subunits Comment Organism
1.2.4.2 ? x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
1.2.4.2 More the catalytic domain of E1o is located at the N-terminus Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

EC Number Synonyms Comment Organism
1.2.4.2 2-oxoglutarate dehydrogenase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.2.4.2 E1o component of the 2-oxoglutarate dehydrogenase multienzyme complex Salmonella enterica subsp. enterica serovar Typhimurium
1.2.4.2 OGDH
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.2 NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.2.4.2 thiamine diphosphate prosthetic group Salmonella enterica subsp. enterica serovar Typhimurium